Nicox Ophthalmics, Inc.

Encore Health LLC

Novartis Ag

Aciex Therapeutics, Inc.

George Edward Minno

Mark Barry Abelson

Matthew Jonathan Chapin

Paul Gomes

Jackie Nice

David M Gooden

Margaret Garner

William Garner

Fiona Patricia Carney

Karen Belinda Sentell

Kasey Jon Minick

Ronald D Blum

Fu-Pao Tsao

Leroy Wainaina Muya

Manal M Gabriel

Walter Lee Nash

Mathew Jonathan Chapin

Willliam Garner

The present invention provides stable topical formulations of cetirizine that provide a comfortable formulation when instilled in the eye and is effective in the treatment of allergic conjunctivitis and/or allergic conjunctivitis. The invention further provides methods of treating allergic conjunctivitis and/or allergic rhinoconjunctivitis in a subject in need of such treatment by topical application of the cetirizine formulations of the invention directly to the eye.

Ophthalmic formulations of cetirizine and methods of use

Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating ocular disease, especially presbyopia and cataract.

Method of treating presbyopia using dithiol compounds and their derivatives

Dithiol compounds, derivatives, and uses therefor

Compounds, formulations, and methods are provided containing the choline ester of a reducing agent, especially lipoic acid or derivatives thereof. The compounds may be administered via a topical ocular route to treat or prevent oxidative damage.

Choline esters

Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating an ocular disease, especially presbyopia and cataract. Also provided are methods of treating an ocular disease, the methods comprising administering to a subject an active agent and an adjunctive agent.

Methods of treating ocular diseases using derivatives of lipoic acid

The present invention relates to improved contact lens products which not only have initial insertion comfort. The contact lens product of the invention comprises a soft hydrogel contact lens immersed and autoclaved in a packaging solution including a low molecular weight polyethylene glycol (PEG) (or glycerin) and a homopolymer or copolymer of vinylpyrrolidone. The present invention also provides methods for making contact lens products of the invention.

Contact lens packaging solutions

Methods of treating ocular diseases using dithiol compounds, their derivatives, and pharmaceutically acceptable salts thereof are disclosed. In particular, methods using dithiol compounds that comprise derivatives of lipoic acid are described. The dithiol compounds are especially useful for treating ocular diseases such as presbyopia and cataract.

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Suwanee, GA, United States of America

George Edward Minno