Miles Inc.

Bayer Corporation

Technicon Instruments Corporation

George E Zabetakis

Paul G Gherson

Alexander F Kerr

Uri Escoli

Edwin H Mernyk

Georges Revillet

David Kleinschmitt

Andre Nicole

Maroun Touma

The method of diluting a fluid sample for analysis in a sample analysis system includes the provision of an aspiration probe with two interior sections. The first interior section of the probe has a first diameter and is proximate the aspiration opening of the probe. The second interior section of the probe has a second diameter of greater magnitude than the first diameter and is located distally of the first section. The probe aspirates in consecutive order selected amounts of fluid sample and diluent into the first interior section of the probe. The fluid sample and diluent are mixed in the second interior section of the probe by moving the sample and diluent back and forth in the second interior section a predetermined number of times. The back and forth movement of diluent and fluid sample in the second interior section of the probe provides substantially uniform mixing of the sample and diluent. The use of a Teflon.RTM. probe coated with fluorocarbon oil eliminates the risk of cross-contaminating the sources of fluid sample and diluent.

Sample dilution module

An apparatus and method for detecting a liquid/gas interface flowing in a transparent tube comprises directing light radially through the transparent tube orthogonal to its longitudinal axis such that the radially directed light passing through the tube when filled with liquid thereat will extend substantially within a predetermined zone and when filled with gas thereat will extend beyond the predetermined zone. Light is received at a position diametrically opposite to a position from which light is directed by receiving only light passing through the tube and extending beyond the predetermined zone. An output signal representative of liquid or gas in the tube is produced in response to the amount of light received. A second light receiver disposed outside the zone is used to determine the direction of flow.

Method and apparatus for discriminating between liquids and gases

Sample liquid analysis apparatus and method for the formation and supply to a conduit of a stream of successive sample liquid test packages, and the repeated bi-directional displacement of the sample liquids test package stream in the conduit, sample liquid analysis apparatus operatively associated with the conduit for repeated, time-spaced analyses in turn of the sample liquids in each of the sample liquid test packages. Each of the test packages comprises a first segment of a sample liquid and a first reagent liquid, and a second segment of a second reagent liquid spaced from the first segment by a different fluid in the test package. The conduit includes a portion to combine the respective first and second segments of each of the test packages upon the flow therethrough to commence the sample and reagent liquids reaction for sample liquid analysis; the sample liquid analysis apparatus is disposed upstream the conduit portion to enable independent analyses of the respective first and second segments of the test packages in turn prior to the combination thereof. Positive displacement pumping, operatively associated with the conduit inlet, or with both the conduit inlet and outlet and, in that event, precisely coupled to provide for differential pumping, for the formation and supply of the test packages in turn to the conduit to form the sample liquids test package stream therein, and for the repeated bi-directional displacement of that stream in the conduit.

Reversible direction capsule chemistry sample liquid analysis system and

The metering device for a slide analysis system deposits serum onto a slide that is held in a spotting position by a slide transfer device. The metering device is movable to a sampling position relative to a slide holding module to aspirate serum from a serum source on a slide cartridge in the slide holding module and is also movable to a spotting position to spot serum on the slide held by the slide transfer device. The metering device also has rotational as well as elevational movement and includes a built-in pipette tip ejector for discarding a used pipette tip.

Metering device for slide analysis system

The slide analysis system includes a slide holding module spaced from an incubator module. A slide transfer device or pick and place mechanism withdraws slides from the slide holding module and inserts them into the incubator module. A metering device deposits serum onto a slide that is held in a spotting position by the slide transfer device. The metering device is movable to a sampling position in the slide holding module to aspirate serum from a serum source on the slide cartridge in the slide holding module and is also movable to a spotting position to spot serum on the slide held by the slide transfer device. The slide transfer device has rotational as well as transverse movement and includes jaws for gripping onto the sides of slides to withdraw a single slide from a cartridge, transport it to the incubator, insert the slide in the incubator and thereafter remove it from the incubator. The metering device also has rotational as well as elevational movement and includes a built-in pipette tip ejector for discarding a used pipette tip.

Growing community of inventors

Bethel, CT, United States of America

George E Zabetakis