Mycogen Corporation

Dow Agrosciences LLC

Hycogen Corporation

George E Schwab

Kenneth Edwin Narva

H Ernest Schnepf

Jewel M Payne

Guy A Cardineau

Mark E Knuth

Michael R Pollard

Tracy Ellis Michaels

Mark Thompson

August J Sick

Luis Foncerrada

Gregory A Bradfisch

Heidi J Uick

John B Randall

Rod Aaron Herman

M Keith Kennedy

Stacey Finstad Lee

Henry Meier

Joanna Dojillo

Jenny M Fu

Brian A Stockhoff

Edward R Wilcox

Frank H Gaertner

Lisa M Stamp

David L Edwards

Paula Burmeister

Andrew William Carr

Theresa Galasan

Yong Gao

Deborah Ann Schwedler

Paula Diehl

Xioaping Xu

Paul Culver

Raymond J Cannon

Leslie A Hickle

Kendrick Akira Uyeda

Harry E Schnepf

This invention provides truncated Cry 35 proteins that surprisingly and unexpectedly have increased pesticidal activity as compared to full-length Cry 35 proteins. The subject invention also includes polynucleotides that encode these truncated proteins, transgenic plants comprising a truncated gene of the subject invention, and transgenic plants that produce these truncated proteins. This invention further provides methods of controlling plant pests, including rootworms, with these truncated proteins. The truncated Cry35 proteins of the subject invention are preferably used in combination with Cry34 proteins, which are known in the art. Various surprising advantages of the subject invention will be apparent in light of this disclosure.

Truncated Cry35 proteins

This invention provides truncated Cry35 proteins that surprisingly and unexpectedly have increased pesticidal activity as compared to full-length Cry35 proteins. The subject invention also includes polynucleotides that encode these truncated proteins, transgenic plants comprising a truncated gene of the subject invention, and transgenic plants that produce these truncated proteins. This invention further provides methods of controlling plant pests, including rootworms, with these truncated proteins. The truncated Cry35 proteins of the subject invention are preferably used in combination with Cry34 proteins, which are known in the art. Various surprising advantages of the subject invention will be apparent in light of this disclosure.

The subject invention concerns new classes of pesticidally active proteins and the polynucleotide sequences that encode these proteins. In preferred embodiments, these pesticidal proteins have molecular weights of approximately 40-50 kDa and of approximately 10-15 kDa.

Pesticidal proteins

The subject invention concerns new classes of pesticidally active proteins and the polynucleotide sequences which encode these proteins. More specifically, in preferred embodiments, pesticidal proteins of approximately 40-50 kDa and of approximately 10-15 kDa are used for controlling corn rootworms. Also described are novel pesticidal isolates of

The subject invention concerns new classes of pesticidally active proteins and the polynucleotide sequences that encode these proteins. In preferred embodiments, these pesticidal protein have molecular weights of approximately 40&#x2013;50 kDa and of approximately 10&#x2013;15 kDa.

The subject invention concerns new classes of insecticidal proteins obtainable from, and polynucleotides that encode these proteins. The subject invention also includes transgenic cells and plants that produce these proteins. The proteins are preferably in the 10-15 kDa and 40-50 kDa size range.

Pesticidal toxins

This invention concerns nematicidal proteins obtainable from isolates. The subject invention also provides various methods of using these proteins for controlling nematodes.

Nematicidal proteins

The subject invention concerns new classes of pesticidal toxins and the polynucleotide sequences which encoded these toxins. Also described are novel pesticidal isolates of

The subject invention concerns new classes of pesticidal toxins and the polynucleotide sequences which encode these toxins. Also described are novel pesticidal isolates of

The subject invention concerns methods and compositions for the selective control of pest. The method involves the administration of an enzyme that disrupts an ecdysteroid metabolic pathway wherein said ecdysteroid pathway exists in said pest but not in mammals, wherein said enzyme catalyzes the reduction of a 3-keto group to a 3&agr;-hydroxyl group, and wherein said 3-keto group is a 3-keto group of a molecule selected from the group consisting of a 3-dehydroecdysone and 3-dehydro-20-hydroxyecdysone.

Materials and methods for pest control

This invention concerns genes or gene fragments which have been cloned from novel Bacillus thuringiensis isolates which have nematicidal activity. These genes or gene fragments can be used to transform suitable hosts for controlling nematodes.

Nematode-active toxins and genes which code therefor

The subject invention concerns new classes of pesticidal toxins and the polynucleotide sequences which encode these toxins. Also described are novel pesticidal isolates of Bacillus thuringiensis.

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La Jolla, CA, United States of America

George E Schwab