Other

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Richard S. Adler

George E Nelson

Richard Steven Adler

Joseph P McFadden

Blake G Sloan

David A Evans

Edwin L Jesse

Jeffrey B Kopp

Michael W Smith

Ferrel Ensign

Randall Johnson

Tore Abrahamsen

Cheryl Winkler

George Hayward

Methods for determining the genetic predisposition of a human subject to developing renal disease, such as focal segmental glomerulosclerosis (FSGS) or end-stage kidney disease are provided herein. These methods include methods for detecting renal disease, or determining the risk of developing renal disease in a human subject, such as a subject of African ancestry. The methods utilize the detection of one or more haplotype blocks comprising at least two tag single nucleotide polymorphisms (SNPs) in a non-coding region of a MYH9 gene or detecting the presence of at least one tag SNP in a non-coding region of a MYH9 gene. An array for detecting a genetic predisposition to renal disease using probes complementary to the tag SNPs in the non-coding region of the MYH9 gene are also disclosed.

Single nucleotide polymorphisms associated with renal disease

A movable barrier wall system includes a housing assembly that has an interior chamber A barrier member is made of a buoyant material having a selected density. The barrier member floats vertically within the chamber when a liquid is present. The barrier member may be made from a closed cell foam core that is clad with a fiberglass mesh material then the assembly is infused with a resin material. Alternatively, the core may be made from a plurality of elongated rods that are individually clad and reinforced with a shear layer. The individual barrier member modules may be assembled in an end to end relationship with an elongated vertical seal member therebetween. The barrier member may be selectively raised prior to and in anticipation of a flood situation of a nearby body of water by a pump and control system that may be automatically or manually controlled. At least one passive backup system is provided for filling the chamber when the pump or control system fails. The system includes a second pump for selective removal of the liquid from the chamber

Movable barrier wall

An automatically-actuated sealing device is disclosed which seals a gap between a door bottom (or edge) and a surface defining part of an opening through which weather, dust, insects, etc. may otherwise pass. The sealing device includes a support element attachable to the door bottom, a seal actuating element movably supported by the support element, a sealing element moved by the seal actuating element into a sealing position, and a plurality of metal, plastic or metal and plastic spring elements which couple the seal actuating element to the support element and urge the seal actuating element to seal the gap. The sealing devices operate by coupling the device to the opening defining surface so that opening and closing of the door generates movement of the seal actuating element. A projection on the seal actuating element is engaged by the door jamb or a bearing element attached to the jamb, and is laterally moved in response to opening and closing the door. In another embodiment, spring elements direct movement of the seal actuating member without lateral movement using a cord attached to the seal actuating element and the opening defining surface. The sealing device may be mounted to either side of or in an edge (mortise-mounted) of the door, and to both right and left-opening doors. A one-piece cover with end caps covers the sealing device. The support element is attached to the door using a few screws; everything else, including the cover and end caps, is attached without fasteners.

Automatic door sweep

A system and method for processing transactions in renewable options in stocks or other securities. The system provides means for entry of customer data and renewable option transaction data, means for processing the data, and means for storing the data. Included in the transaction data is data regarding the criteria under which the renewable option investment will be renewed, as well as data indicating the renewal premium for renewing the renewable option, which may be a fixed amount or an amount based on additional data. Through this system, the renewable option may be renewed periodically for a fixed period, until a designated event occurs, or perpetually. Means for storing criteria under which the renewable options are exercised, sold, or allowed to expire, and for processing the exercise, sale, or expiration of such renewable options, are also disclosed. Also disclosed is a method for processing transactions in such renewable options.

Renewable option accounting and marketing system

Desk

Growing community of inventors

Monroe, CT, United States of America

George E Nelson