Cynosure, Inc.

George E Cho

Horace W Furumoto

Rafael Armando Sierra

David H McDaniel

James Henry Boll

Eric Calvin Koschmann

Antonio G Rizzo

Anthony P Burns

Ying Hsaing Cho

Mirko Georgiev Mirkov

Brian D Zelickson

Harry L Ceccon

Evan Sherr

Mark P Hacker

Roger P Veilleux

Jamie Koufman

Disclosed herein are methods and systems for treatment, such as skin rejuvenation treatment, use non-uniform laser radiation. A high-intensity portion of the laser radiation causes collagen destruction and shrinkage within select portions of the treatment area, while a lower-intensity portion of the radiation causes fibroblast stimulation leading to collagen production across other portions of the treatment area. An output beam from a laser source, such as an Nd:YAG laser, is coupled into an optical system that modifies the beam to provide a large-diameter beam having a nonuniform energy profile, comprised of a plurality of high-intensity zones surrounded by lower-intensity zones within the treatment beam. The higher-intensity zones heat select portions of the target tissue to temperatures sufficient for a first treatment (e.g. collagen shrinkage), while the lower-intensity zones provide sufficient energy for a second treatment (e.g. stimulated collagen production).

Methods and systems for laser treatment using non-uniform output beam

A method for the treatment of wrinkles on human skin, by stimulating collagen growth beneath the epidermis layer, comprising the steps of: arranging a pulsed dye laser generator in light communication with a pulsed dye laser delivery device. The pulsed dye laser delivery device is applied against tissue having wrinkles. The pulsed dye laser generator generates a pulsed dye laser light. A pulsed dye laser light from the pulsed dye laser delivery device is directed onto the tissue, to reach hemoglobin in a collagen layer up to about 1.2 mm. beneath the surface of the tissue to effect growth changes therein.

Method for non-invasive wrinkle removal and skin treatment

Apparatus for the treatment of Barrett's esophagus, including: an inflatable balloon for insertion into the esophagus, an endoscope for passing inside the balloon on a distal end thereof, a laser fiber apparatus for insertion within the balloon in the esophagus, and a balloon inflation/deflation means in fluid communication with the balloon for inflating and emptying the balloon into and out of contact with the walls of the esophagus to be treated. The balloon may occlude the stomach from the esophagus during treatment.

Esophageal lesion treatment method

A method for the treatment of Barrett's Esophagus of a patient having endothelial esophageal complications. The treatment comprises connecting a wavelength specific light source to an elongated light guide having a distal end, the light guide arranged within a lumen of a steerable endoscope, guiding the endoscope into the esophagus of the patient, energyzing the light source, and manipulating the distal end of the light source onto a target on the endothelial complications inside of the patient's esophagus for the selective thermolysis of the target in the esophagus, thereby reverting the red secretory esophageal lining to a normal lining.

Arrangement for the treatment of barrett's esophagus

A method for the reduction in healing time for a wound on the skin of a mammalian patient. The method comprises the steps of providing an optical radiation apparatus with a handpiece communicating therewith, energyzing the optical radiation apparatus to provide a beam of light, and directing the light beam onto a wound or surgical site of a patient. The beam has a wavelength range of about 530 nm to 1000 nm and the beam has a fluence range of from 2 J/cm to 5 J/cm . The beam is preferrably generated by a pulse dye laser apparatus.

Optical radiation treatment for enhancement of wound healing

A delivery guide frame attachment for a laser scanner mechanism for a laser treatment operation, to permit proper spacing and dimensional stability of the laser scanner with respect to the skin of a patient being treated. The delivery guide frame attachment includes a housing having an upper end and a lower end. The lower end is applyable to the skin of a patient. The upper end is attached to the laser scanner. A chilled fluid supply conduit is arranged in communication with the housing for delivering a chilled fluid onto the skin of a patient when the housing is applied thereto. A chilled fluid containment arrangement in the housing retains and delays escape of chilled fluid from the housing placed on the patient, for a short period during the laser treatment operation.

Cooling delivery guide attachment for a laser scanner apparatus

A long pulse alexandrite laser hair removal system is disclosed using light pulses of greater than 1 msec and fluences between 10 and 50 J/cm . The use of an alexandrite laser allows good penetration while still achieving an acceptable combination of hemoglobin and melanin absorption. The use an index-matching application on the skin sections to be treated is also described. This substance will be absorbed into the epidermal layer to provide better coupling of the laser light into the skin. Also, and most advantageously, it will reduce reflections at the epidermal-dermal junction, which can lead to the damage of the skin. Also a topical thermal or photochromic indicator is suggested since skin irradiation in the near-infrared generally does not produce any characteristic skin color change as is found when using pulsed dye lasers, for example.

Alexandrite laser system for hair removal and method therefor

The present invention comprises an assembly for the single-hand manipulation of a light treatment device and a chilled air supply on a skin light-treatment site. The assembly comprises an elongated frame member having a first end and a second end. The frame member also has an upper portion and a lower portion, the upper portion having an elongated channel therealong for receipt of a light emitting optics for emitting a light beam therefrom. The lower portion has a bore extending therethrough for passage of chilled air from a chilled air source. The bore may be arranged to direct chilled air at an angle with respect to the light beam to chill the site. The assembly includes a handpiece tip member arranged at the second end of the frame assembly and maybe integral therewith. A flexible chilled air supply hose made of light weight foam material and reinforced with an expandable sleeve member connects a refrigeration unit to the frame assembly.

Chill frame for lasers

A method for the prevention of a scar on the skin of a patient after the beginning healing of a wound or surgical site on that patient. The method comprises the steps of providing an optical radiation apparatus with a handpiece communicating therewith, energizing the optical radiation apparatus to provide a beam of light, directing the light beam onto a wound or surgical site of a patient after 2 days and before 2 months from the date of injury or surgical procedure to the patient. The beam has a wavelength range of about 530 nm to 1000 nm and the beam has a fluence range of from 2 J/cm,to 12 J/cm,. The beam is preferrably generated by a pulsed dye laser apparatus.

Optical radiation treatment for prevention of surgical scars

A long pulse alexandrite laser hair removal system is disclosed using light pulses of greater than 1 msec and fluences between 10 and 50 J/cm.sup.2. The use of an alexandrite laser allows good penetration while still achieving an acceptable combination of hemoglobin and melanin absorption. The use an index-matching application on the skin sections to be treated is also described. This substance will be absorbed into the epidermal layer to provide better coupling of the laser light into the skin. Also, and most advantageously, it will reduce reflections at the epidermal-dermal junction, which can lead to the damage of the skin. Also a topical thermal or photochromic indicator is suggested since skin irradiation in the near-infrared generally does not produce any characteristic skin color change as is found when using pulsed dye lasers, for example.

A combined sclerotherapy and light treatment method is described for the treatment of unwanted veins such as varicose and telangiectatic leg veins. Substantially increased success, in the range of 90-100%, has been achieved by implementing a dwell time of between 12 hours and 6 months between the light-based therapy and the sclerotherapy. Near infra-red wavelength light is preferably used in the light therapy due to its better depths of penetration through the skin to deeper lying, larger vessels such as varicose veins.

Method for treatment of unwanted veins and device therefor

An endoscopic light delivery system for delivering light to tissue includes a laser source for generating light. Fiber optics encased in a plastic buffer are optically coupled to the laser source for conveying the light generated by the laser source. A tip member secured to the fiber optics positions a mirror adjacent to the light delivery end of the fiber optics. The mirror redirects light conveyed by the fiber optics in a direction lateral to the fiber optics. A heat resistant ring encircling the fiber optics near the light delivery end shields the fiber optics from heat to prevent the plastic buffer near the light delivery end from melting. A lateral extension of the tip member spaces the mirror and fiber optics away from tissue. A band with a circumferential groove encircles the light receiving end of the fiber optics. A connector having a bore is capable of receiving the light receiving end of the fiber optics in the bore and locking the band within the bore by engaging the groove with a locking device.

Endoscopic light delivery system

The present invention involves a system for transmyocardial revascularization of a beating heart, including a laser device for ablating wall tissue of the heart being treated, with a pacemaker connected to the heart being treated, to provide electrical signals to control the cardiac cycle of that heart, and a conditioning circuit connected to both the pacemaker and to the laser, to permit the controlled 'safe period' firing of the laser. The laser includes an optic waveguide articulably arranged to irradiate the wall of the heart. The conditioning circuit is programmed to permit the firing of the laser upon the time of the cardiac cycle of the heart during a non-ventricular repolarization time period.

Growing community of inventors

Hopkinton, MA, United States of America

George E Cho