Worcester Polytechnic Institute

George D Pins

Kristen Billiar

Kevin G Cornwell

Glenn R Gaudette

Adam Collette

William Edelman

The present invention relates, in part, to sutures which promote wound closure and/or healing. In particular, the present invention provides fibrin microthread sutures that mimic the mechanical behavior of a target tissue thereby reducing, for example, scarring, inflammation, and cell death at the ligature site, including monofilament sutures.

Compositions and methods for wound healing

Compositions that include fibrin microthreads are provided. The compositions can include one or more therapeutic agents including cytokines and interleukins, extracellular matrix proteins and/or biologically active fragments thereof (e.g., RGD-containing peptides), hormones, vitamins, nucleic acids, chemotherapeutics, antibiotics, and cells. Also provided are methods of making compositions that include fibrin microthreads. Also provided are methods for using the compositions to repair or ameliorate damaged or defective organs or tissues.

Fibrin microthreads

Collagen and fibrin microthreads in a discrete thread model of in vitro ACL scaffold regeneration

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Holden, MA, United States of America

George D Pins