Cerus Corporation

Steritech, Inc.

Baxter International Inc.

Other

Hri Research, Inc.

Fenwal, Inc.

Lawrence Livermore National Security, LLC

Carus Corporation

George D Cimino

Stephen T Isaacs

John E Hearst

Lily Lin

Peyton S Metzel

David Paul Hearst

Derek J Hei

Mahmood Mohiuddin

Paul Franzosa

Michael S Clarke

Serge De Gheldere

Peter R H Stark

John W Tessman

Wendy M Power

Peter G Carroll

Romilly John Simms

Daniela Homza Stark

Kathleen A Hanley

David F Beittel

Lawrence Corash

David P Hearst

Peter Stark

Yuanpang Samuel Ding

Daniel F Bischof

James Laird

Laurence Corash

Paul Henderson

Chong-Xian Pan

Kenneth W Turteltaub

Robert E Herman

Veronique Mayaudon

Jeffrey M Waldo

Joseph S Moore

Kenneth C Metchette

Ralph William De Vere White

Maike Zimmermann

Walter Page Hatch

Carl V Hanson

Yu S Zhu

John Tessman

Gregory Soudant

Paul A Franzosa

Walter Stark

The invention relates to methods, systems and kits for determining therapeutic effectiveness or toxicity of cancer-treating compounds that incorporate into or bind to DNA. In particular, the invention is directed to methods, systems and kits for predicting a patient's treatment outcome after administration of a microdose of therapeutic composition to the patient. The methods provides physicians with a diagnostic tool to segregate cancer patients into differential populations that have a higher or lower chance of responding to a particular therapeutic treatment.

Methods for cytotoxic chemotherapy-based predictive assays

Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to the fluid treatment chamber. A drawer for holding containers of biological fluid introduces the containers into the chamber. Containers for holding the biological fluid are marked by the apparatus to indicate the status of the treatment.

Apparatus, and systems for processing and treating a biological fluid with light

Apparatus (), systems and methods are disclosed for treating a biological fluid with light. A container () of biological fluid is introduced into a fluid treatment chamber () where it is contacted with light provided by one or more light sources () in proximity to the fluid treatment chamber (). A light sensing system () senses the intensity of illumination of the light. A radiometer () may be inserted into fluid treatment chamber () to calibrate the light sensing system (). An electronic control system () utilizes an interface circuit board () to interface a computer circuit board () to a display panel (), a user interface panel (), a relay circuit board (), light sensorsand various other sensors (). A detector () senses agitating movement of a tray () that contains biological fluids. Methods include calibrating (-), sensing (-) and correcting (-) light intensity measurements, and determining the length of treatment () to reach a desired illumination dose. A radiometer () is equipped with a plurality of light sensors () disposed on both sides to measure light intensity in chamber () and to provide a reference for calibrating light sensing system ().

Apparatus, systems and methods for processing and treating a biological fluid with light

Processing set and methods for processing and treating a biological fluid

Apparatus (), systems and methods are disclosed for treating a biological fluid with light. A container () of biological fluid is introduced into a fluid treatment chamber () where it is contacted with light provided by one or more light sources () in proximity to the fluid treatment chamber (). A light sensing system () senses the intensity of illumination of the light. A radiometer () may be inserted into fluid treatment chamber () to calibrate the light sensing system (). An electronic control system () utilizes an interface circuit board () to interface a computer circuit board () to a display panel (), a user interface panel (), a relay circuit board (), light sensorsand various other sensors (). A detector () senses agitating movement of a tray () that contains biological fluids. Methods include calibrating (), sensing () and correcting () light intensity measurements, and determining the length of treatment () to reach a desired illumination dose. A radiometer () is equipped with a plurality of light sensors () disposed on both sides to measure light intensity in chamber () and to provide a reference for calibrating light sensing system ().

Processing set for processing and treating a biological fluid

Methods and compositions are described for treating contaminants in material intended for in vivo use, and in particular blood and blood products for human use. Contaminants in blood cell preparations are inactivated prior to long term storage and transfusion. Inactivation is accomplished using a device having a unique temperature control design.

Device and method for photoactivation

A device containing a light source, a sample support and a temperature control compartment. The sample support is positioned to support multiple sample vessels for irradiation by the light source. The temperature control compartment maintains the temperature of the sample vessels within a desired range. The light source, sample support and temperature control compartment are all contained within an opaque housing.

A device comprising a light source, a sample holder and a temperature control chamber. The sample holder supports the vessels in a fixed relationship relative to the light source. The temperature control chamber surrounds the sample holder and vessels, so that a temperature control fluid may be passed around the sample vessels effectively maintaining the temperature of the sample vessels within a desired temperature range.

Containers and methods for making containers are disclosed. The containers include a chamber and a pouch fixed within the chamber. During manufacture, the open edges of the pouch are sealed between the walls of the container by a seal defining, in part, the peripheral edge of the chamber.

Plastic containers having inner pouches and methods for making such containers

Growing community of inventors

Lafayette, CA, United States of America

George D Cimino