Lankenau Institute for Medical Research

The Wistar Institute

Sloan-kettering Institute for Cancer Research

Newlink Genetics Corporation

Lankenau Institute for Medcial Research

George C Prendergast

Alexander J Muller

William Malachowski

Daitoku Sakamuro

Richard Metz

James Duhadaway

James B DuHadaway

Iraimoudi S Ayene

James Mullin

Kai Ge

James B Duhadaway

Samuel L Graham

Firoz Jaipuri

Mario Mautino

Neal Rosen

Charles J Link

Allen I Oliff

Jesse Waldo

Sanjeev Kumar

Laura Sepp-Lorenzino

Aidan Hyde

Tanay Kesharwani

Nicholas N Vahanian

Jackson B Gibbs

Arturo Bravo-Nuevo

Arpita Mondal

Sunil Thomas

Lisa Laury-Kleintop

Souvik Dey

Thomas Sunil

Dylan Paproski

Christopher Scholl

Barbara Merle Gilmore

Barbara Wadsworth

Andrew Mazzotta

Laura Mandik-Nayak

Judith Lalonde

Nancy Kohl

Mark M Moasser

William P Malachowski

A personal injury mitigation device for sensing a fall condition and responsively deploying a protective device in bathrooms or other elevated-risk spatial environments. A fall sensing system of the device includes a sensor and an analysis module that processes a signal from the sensor to determine whether a fall condition exists, and if so, transmits a trigger signal to a deployment system. The deployment system includes a stored energy system and an actuation system operable to release stored energy in response to receipt of the trigger signal. An impact mitigation device receives the released energy from the deployment system, which causes deployment of a protective device (such as an airbag) from a housing in which the protective device is stored in a compact state. In the deployed state, the protective device is operable to protect a person against injury due to impact resulting from a fall.

Device for mitigation of personal injuries due to falls

The nucleotide and amino acid sequences of indoleamine 2,3-dioxygenase-2 (IDO2) and methods of use thereof are provided.

Nucleic acid molecules encoding indoleamine 2,3-dioxygenase-2

Compositions and methods for the treatment of an ocular disease or disorder are disclosed.

Methods and compositions for the treatment of ocular diseases and disorders

Compositions and methods for the treatment of a disease or disorder are disclosed. Specifically, methods for inhibiting, treating, and/or preventing inflammatory disease in patients in need thereof are provided. The methods comprise the administration of at least one antibody or antibody fragment immunologically specific for bridging integrator I (Bin 1), particularly the Myc binding domain.

Methods and compositions for the treatment of diseases and disorders

Compositions and methods for the treatment of a disease or disorder are disclosed.

Anti-RhoB antibodies, compositions comprising the same, and methods for the treatment of autoimmune and inflammatory diseases using the anti-RhoB antibodies are disclosed.

Anti-RhoB antibodies

Compositions and methods for the treatment of cancer are provided.

Disulfide chemotherapeutic agents and methods of use thereof

Presently provided are compounds according to the formula (I) or (II), and pharmaceutical compositions comprising the compounds, wherein R, R, and Rare defined herein. Such compounds and compositions are useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosuppression associated with an infectious disease. 

IDO inhibitors

Compounds, compositions and methods for the treatment of malignancy are disclosed.

IDO inhibitors and methods of use

Indoleamine 2,3-dioxygenase-2 antibodies

Novel indoleamine 2,3-dioxygenase (IDO) inhibitors, compositions comprising the same, and methods of use thereof are disclosed.

IDO inhibitors and methods of use thereof

Compositions and methods for the treatment of malignancy and chronic viral infection are disclosed.

Methods for the treatment of cancer

Growing community of inventors

Penn Valley, PA, United States of America

George C Prendergast