The Government of the United States of America, As Represented by the Secretary of Homeland Security

The Dupont Merck Pharmaceutical Company

Dupont Pharmaceuticals Company

George C Emmett

David A Reed

Prabhakar Kondaji Jadhav

Michael Ernest Pierce

In an example, a method of detecting cyanide exposure of an individual includes: measuring a thiocyanate level of the individual which includes placing saliva of the individual in contact with a chemical indicator to measure the thiocyanate level and measuring thiocyanate (SCN) catalyzed by enzyme rhodanese of the individual; comparing the measured thiocyanate level to a preset thiocyanate threshold to determine whether the measured thiocyanate level is above the preset thiocyanate threshold indicating a level of cyanide poisoning for which a medical procedure is recommended to manage health effects of the exposure; and performing the medical procedure if the measured thiocyanate level is above the preset thiocyanate threshold and not performing the medical procedure if the measured thiocyanate level is not above the preset thiocyanate threshold.

Detecting cyanide exposure based on thiocyanate measurement in saliva

In an example, a method of detecting cyanide exposure of an individual comprises measuring a thiocyanate level of the individual, and comparing the measured thiocyanate level to a preset thiocyanate threshold to determine whether the measured thiocyanate level is above the preset thiocyanate threshold indicating a level of cyanide poisoning requiring immediate medical assessment.

Detecting cyanide exposure based on thiocyanate measurement

In an example, a method of detecting cyanide exposure of an individual comprises measuring a thiocyanate level of the individual, and comparing the measured thiocyanate level to a preset thiocyanate threshold to determine whether the measured thiocyanate level is above the preset thiocyanate threshold indicating a level of acute cyanide poisoning for which medical treatment is recommended to treat health effects of the exposure.

System and method for detecting cyanide exposure

This invention relates to methods for preparing alkylating agents and use of the agents prepared. In particular, this invention relates to preparation methods for hydroxy halide and organooxy halide alkylating agents and their use for alkylating cyclic urea compounds.

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Wilmington, DE, United States of America

George C Emmett