University of California

Osmic, Inc.

Other

Ovonic Synthetic Materials Company Inc.

Advanced X-ray Technology, Inc.

George A Gutman

K George Chandy

J Jay Gargus

Kanianthara G Chandy

Emmanuelle Fantino

Katarin Kalman

Licai Jiang

Boris Verman

Brent A Dethlefs

Michael D Cahalan

Stephan Grissmer

G Wesley Hatfield

Katalin Kalman

Alan L Goldin

John J Wasmuth

Sanjiu Ghanshani

David J Crowther

Grischa Chandy

The present invention is based on the discovery and cloning of the human small conductance calcium activated potassium channel type 3 (hKCa3/KCNN3) gene, which is expressed in neuronal cells, skeletal muscle, heart, and lymphocytes. Alterations in the hKCa3/KCNN3 gene or its protein product may enhance susceptibility to schizophrenia and/or bipolar disorder. hKCa3/KCNN3 may be involved in neuropsychiatric, neurological, neuromuscular, and immunological disorders. Substantially purified hKCa3/KCNN3 polypeptides and polynucleotides are provided. Antibodies which bind to hKCa3/KCNN3 polypeptides are also disclosed. A method for identifying a compound which affects hKCa3/KCNN3 polynucleotide or polypeptide is provided. A method for diagnosis and determining the prognosis and treatment regimen of a subject having or at risk of having a hKCa3/KCNN3-associated disorder is also provided. A method of treating a subject having or at risk of having an hKCa3/KCNN3-associated disorder by administering a therapeutically effective amount of a polynucleotide encoding SEQ ID NO:2 is also provided. A formulation for administration of hKCa3/KCNN3 to a patient of a therapeutically effective amount of hKCa3/KCNN3 polypeptide is provided. Kits useful for detecting the presence of hKCa3/KCNN3 polypeptide or polynucleotide in a sample from a subject having a hKCa3/KCNN3-associated disorder are provided. Transgenic nonhuman animals having a transgene encoding hKCa3/KCNN3 are also described.

hKCa3/KCNN3 small conductance calcium activated potassium channel: a diagnostic marker and therapeutic target

An x-ray imaging apparatus for mammography. The apparatus places the focal spot of the x-ray source as close as possible to a compression paddle or into a desired region of tissue. The apparatus comprises an x-ray source, a collimator with conditioning optics which focus and direct x-ray radiation to a metal pseudo-target in the collimator or a needle placed along the x-ray beam, paddles for breast compression and a detector. The pseudo-target re-emits monochromatic x-ray radiation with an energy, intensity, and space distribution that are adjustable in accordance with a desired imaging procedure.

X-ray imaging apparatus and method for mammography and computed tomography

hKCa3/KCNN3 small conductance calcium activated potassium channel: A diagnostic marker and therapeutic target

An x-ray system for treatment cancer by delivering x-ray radiation directly to a desired region of tissue comprising an x-ray source with directed narrow space distribution of x-rays (linear accelerator), conditioning optics which direct and monochromotize x-ray radiation, an implantable needle with means for shaping beam installed across the x-ray beam, and expanding pipe-guide connecting conditioning optics with implantable needle whereby the energy, intensity, and space distribution of the delivered to the tumor x-ray radiation may be adjusted in accordance with the predefined treatment requirements.

X-ray system with implantable needle for treatment of cancer

An X-ray source is provided for delivering a high intensity X-ray beam with a predefined energy level of monochromatization, intensity and spatial distribution to a desired region of a sample. The source includes a linear accelerator with a thin anode an electron trap for separating an electron beam from an X-ray beam and conditioning optics which direct, shape and monochromatize the X-ray beam. The conditioning optics include a housing within which are contained entrance slits, multi layer Kirkpatrick-Baez mirrors, exit slits, and a stop diaphragm. The invention also include a method of generating X-rays and a method of using them.

Apparatus and method for generating a high intensity X-ray beam with a selectable shape and wavelength

The present invention is based on the discovery and cloning of the human small conductance calcium activated potassium channel type 3 (hKCa3/KCNN3) gene, which is expressed in neuronal cells, skeletal muscle, heart, and lymphocytes. Alterations in the hKCa3/KCNN3 gene or its protein product may enhance susceptibility to schizophrenia and/or bipolar disorder. hKCa3/KCNN3 may be involved in neuropsychiatric, neurological, neuromuscular, and immunological disorders. Substantially purified hKCa3/KNN3 polypeptides and polynucleotides are provided. Antibodies which bind to hKCa3/KCNN3 polypeptides are also disclosed. A method for identifying a compound which affects hKCa3/KCNN3 polynucleotide or polypeptide is provided. A method for diagnosis and determining the prognosis and treatment regimen of a subject having or at risk of having a hKCa3/KCNN3-associated disorder is also provided. A method of treating a subject having or at risk of having an hKCa3/KCNN3-associated disorder by administering a therapeutically effective amount of a polynucleotide encoding SEQ ID NO:2 is also provided. A formulation for administration of hKCa3/KCNN3 to a patient of a therapeutically effective amount of hKCa3/KCNN3 polypeptide is provided. Kits useful for detecting the presence of hKCa3/KCNN3 polypeptide or polynucleotide in a sample from a subject having a hKCa3/KCNN3-associated disorder are provided. Transgenic nonhuman animals having a transgene encoding hKCa3/KCNN3 are also described.

hKCa3/KCNN3 small conductance calcium activated potassium channel: a

An x-ray reflecting system comprising a Kirkpatrick-Baez side-by-side optic in a single corner configuration having multi-layer Bragg x-ray reflective surfaces.

Single corner kirkpatrick-baez beam conditioning optic assembly

An x-ray reflecting system comprising a plurality of x-ray reflectors, wherein the x-ray reflectors are coupled together to form a Kirkpatrick-Baez side-by-side system of multiple corners and may include multi-layer or graded-d multi-layer Bragg x-ray reflective surfaces.

Multiple corner Kirkpatrick-Baez beam conditioning optic assembly

This disclosure relates to the n K.sup.+ channel expression product of the MK3 gene or a functionally bioactive equivalent thereof and its uses, particulary in combination with identifying immune responses and materials modulating or blocking same.

Assay, methods and products based on n K.sup.+  channel expression

This invention relates to novel methods of producing flat and curved optical elements with laterally and depth graded multilayer thin films, in particular multilayers of extremely high precision, for use with soft and hard x-rays and neutrons and the optical elements achieved by these methods. In order to improve the performance of an optical element, errors in d spacing and curvature are isolated and subsequently compensated.

Optical element of multilayered thin film for x-rays and neutrons

An optical system for providing a steerable monochromatized source of x-ray or neutron radiation. The system incorporates a radiation source and a Bragg structure reflective optical element. A stage causes the optical element to move relative to the radiation source. Such movement is coordinated with lateral d-layer grading such that Bragg's law of reflection is satisfied for radiation of a given wavelength bandwidth to be reflected at various instances and departure angles.

Steerable x-ray optical system

Optical element of multilayered thin film for X-rays and neutrons

This disclosure relates to the identification of a new voltage-gated potassium channel gene, Kv1.7, which is expressed in pancreatic .beta.-cells. The invention utilizes this new potassium channel for assays designed to identify extrinsic materials with the ability to modulate said channel for the development of therapeutics effective in the treatment of non-insulin-dependent diabetes mellitus.

Voltage-gated potassium channel gene, KV1.7, vectors and host cells

This disclosure relates to the general diagnosis and treatment of autoimmune diseases with materials identified in assays based upon the finding herein that such diseases manifest by elevated numbers of type l K.sup.+ channels in abnormal CD4.sup.- CD8.sup.- T cells.

Assay for and treatment of autoimmune diseases

X-ray dispersive elements comprise a stacked array of layer pairs of boron nitride and either nickel, tungsten, chromium, vanadium, iron, manganese, cobalt and combinations thereof. The boron nitride is preferably deposited through a planar magnetron sputtering process.

Growing community of inventors

Costa Mesa, CA, United States of America

George A Gutman