American Cyanamid Company

George A Ellestad

William J McGahren

Martin L Sassiver

Philip R Hamann

Janis Upeslacis

Lois M Hinman

Bryan M O'Hara

Antonina A Nikitenko

Yakov Gluzman, Deceased

Weidong Ding

Darren Abbanat

Valerie Bernan

Yuri E Raifeld

Wei-Dong Ding

Boris Mitsner

John E Morin

James P LaRocque

This invention provides triazine ring containing anionic compounds, pharmaceutical compositions containing these compounds and methods utilizing these compounds for treating viral infections, particularly infections by respiratory syncitial virus, the compounds having the general structure: ##STR1## and the pharmaceutically acceptable salt thereof.

Triazine containing anionic compounds useful as antiviral agents

A process is described for producing substituted disulfide analogs of the family of antibacterial and antitumor agents known collectively as the LL-E33288 complex.

Antitumor and antibacterial substituted disulfide derivatives prepared

This disclosure describes a method for constructing targeting agent drug conjugates from the family of methyltrithio antibacterial and antitumor agents.

Process for preparing targeted forms of methyltrithio antitumor agents

This disclosure describes disulfide analogs of the family of antibacterial and antitumor agents known collectively as the LL-E33288 complex.

This invention relates to antibiotic 42D005.alpha. and 42D005.beta. derived from the microorganism Kitasatosporia, which is useful as an antibacterial agent.

Antibiotic 42D005 .alpha. and .beta.

This disclosure describes a method for constructing carrier-drug conjugates from the family of methyltrithio antibacterial and antitumor agents.

Targeted forms of methyltrithio antitumor agents

Processes for producing antibacterial and antitumor agents designated LL-E33288.epsilon.I and LL-E33288.epsilon.-Br using triphenylphosphine or a sulfhydryl-containing reagent are disclosed. Processes for producing reductively aromatized derivatives of other antibiotics are also disclosed.

Process for producing the antibiotic and antitumor agents LL-E33288.epsilon

Processes for producing antibacterial and antitumor agents designated LL-E33288.epsilon.-I and LL-E33288.epsilon.-Br using triphenylphosphine at ice bath temperature are disclosed. Novel intermediates prepared in the processes are also disclosed.

Intermediate and process for producing the antibacterial and antitumor

Antibacterial and antitumor agents designated LL-E333288.epsilon.-I and LL-E33288.epsilon.-Br and their production by strains of Micromonospora echinospora ssp. calichensis designated NRRL-15839, NRRL-15975 and NRRL-18149, are disclosed.

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Pearl River, NY, United States of America

George A Ellestad