Alphaport, Inc.

Ambrigen, LLC

George A Adaniya

Paul V Fenton

Nigel G Skinner

An implant injection system and method for introducing a bone implant material into a patient's bone to serve as an anchor or to fill a void in the bone. The system and method provide a quantity of meltable material which is melted in situ so that the melted material can flow and diffuse into, and be anchored to, the cancellous bone portion beneath the cortical bone layer. The flowing of the bone implant material can be accomplished by a heater located at the distal end of the implant injection system. The implant material may be provided in multiple layers with an inner layer having a lower flowing temperature than the outer layers. There can also be a looped suture that passes though the meltable material, with the free ends of the suture extending outwardly to be tied to soft tissue to affix the soft tissue to the bone.

Method and injection system for bone tissue implant

The invention provides a particle comprising a surface, wherein a portion of the surface is capable of emitting electromagnetic radiation and another portion of the surface is capable of emitting a differential electromagnetic radiation (either different intensity, different frequency or no radiation), and wherein the arrangement of said portions of the surface defines a spatially distributed code for identifying the particle. The invention also provides method of manufacturing a particle having an identifying code comprising providing a particle with a functionalized surface which comprises functional binding moieties and selectively removing a plurality of the functional binding moieties from the surface to create a pattern of functionalized and differentially-functionalized zones on the surface. Various liquid-based assay methods employing the particle of the invention and a kit comprising the particle of the invention are also disclosed.

Assay based on particles, which specifically bind with targets in spatially distributed characteristic patterns

An implantable access device including a port for receiving and guiding a filament, such as a needle, into an entry region of the device. The port includes a plate for receiving a filament, and at least two walls extending upwardly from the plate. The walls are shaped and positioned to guide the filament moving between opposing first and second ends of the plate through an entry region defined between the walls at the second end of the plate. Preferably, a greatest distance between the walls is at least five times greater than a height of the walls, so that the port provides a large filament strike area, yet has a small overall height. In addition, a greatest distance between the ends of the plate is also preferably at least five times greater than the height of the walls, to further increase the filament strike area without increasing height.

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Wellesley, MA, United States of America

George A Adaniya