Schering Aktiengesellschaft

Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg

Georg Rossling

Andreas Sachse

Celal Albayrak

Wolfgang Schmidt

Udo Johannes Vetter

Helmut Vetter

Johannes Wilhelm Tack

Jutta Riedl

Thomas Otto

Hans-Ulrich Moritz

Jan-Peter Ingwersen

Kai Lovis

Andreas Briel

Uwe Budde

Jens Leike

The invention relates to a multi-stage method for producing gas-filled microcapsules. In one stage of the method, the substance that forms the coat is polymerized. The microcapsules are formed in a physically and/or temporally separate stage, by means of a structuring process. The polymerization is carried out with moderate stirring, while the microcapsules are structured in dispersing conditions.

Multi-stage method for producing gas-filled microcapsules

A process for increasing the stability of liposome suspensions that contain hydrophilic active ingredients is described, which is characterized in that the active ingredient that is to be encapsulated in the liposomes is metered such that 5% to 95% by weight of the active ingredient is present in unencapsulated form.

Process for increasing the stability of liposome suspensions that contain hydrophilic active ingredients

Use of methylenemalondiester derivatives for the production of

A hypodermic syringe has a tubular body extending along and centered on an axis and having an axially forwardly open front end, a piston rod axially displaceable in the body and having a plunger rod extending rearwardly from the body, and a plug fitted into the front end and forming an axially through-going passage. An elastomeric membrane is provided in the plug traversing and blocking the passage. Furthermore structure fixed to the plug includes a point in the passage spaced axially slightly forward of the membrane so that the membrane can be deformed axially forward to engage and be pierced by the point.

Prefilled hypodermic syringe

A method of using cavitate- or clathrate-forming host/guest complexes for the preparation of contrast media in ultrasonic examination is provided. The host/guest complexes have a host which dissolves in a liquid carrier, releasing the guest (inert gas). With such contrast media, it is possible to diagnose blood and its flow conditions in the heart, and other organs, such as the myocardium, liver, spleen, and kidneys. Other internal systems such as the urinary ducts, the gastrointestinal tract, joints, and eyes can also be imaged.

Preparation comprising cavitate-  or clathrate-forming host/guest

Pharmaceutical preparations are provided comprising antiandrogenically effective substances encapsulated in liposomes. These preparations are preferably used for topical treatment of androgen-dependent diseases.

Pharmaceutical preparations

A process is described for the production of aqueous dispersions involving removal of liquid(s) from an optionally multiphase liquid mixture by means of membrane distillation, e.g., transmembrane distillation or pervaporation.

Aqueous dispersion containing liposomes

Process for the preparation of aqueous dispersions

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Berlin, Germany

Georg Rossling