Byk Gulden Lomberg Chemische Fabrik Gmbh

Bayer Aktiengesellschaft

Georg Rainer

Bernhard Kohl

Gerhard Grundler

Gerhard Wolfrum

Richard Sommer

Ernst Sturm

Ulrich Thibaut

Volker Figala

Imidazopyridine azolidinones

Alkoxy alkyl carbamates of imidazo(1.2-a)pyridines

Pharmaceutically useful imidazopyridines

Dialkoxypyridines of formula I ##STR1## wherein R1 is 1-3C-alkyl which is completely or predominantly substituted by fluorine, or a chlorodifluoromethyl radical and

Fluoroalkoxy substituted benzimidazoles useful as gastric acid secretion

Picoline derivatives of the formula I ##STR1## wherein the substituents have the meanings given in the description, and their salts are new compounds having a pronounced protective action on the stomach.

Picoline derivative useful as gastric acid secretion inhibitors

Tricyclic ethers of the general formula I ##STR1## wherein R represents a bond and R1 represents a 1-2C-alkylene radical which is completely or partly substituted by fluorine, or a chlorotrifluoroethylene radical, or R and R1 each represent a difluoromethylene radical, R2 represents hydrogen or a 1-3C-alkyl radical, R3 represents hydrogen or a 1-3C-alkyl or 1-3C-alkoxy radical, R4 represents hydrogen or a 1-3C-alkyl radical and n represents the number 0 or 1, and their salts are new compounds with a marked protective effect on the stomach.

[1,3]-Dioxolo[4,5-f]benzimidazoles and [1,4]-dioxino[2,3-f]benzimidazoles

Fluoroalkoxy compounds of the general formula I ##STR1## wherein R1 represents a 1-3C-alkyl radical which is completely or predominantly substituted by fluorine, or a chlorodifluoromethyl radical, R1' represents hydrogen, halogen, trifluoromethyl, a 1-3C-alkyl radical, or a 1-3C-alkoxy radical which is optionally completely or predominantly substituted by fluorine, R2 represents hydrogen or a 1-3C-alkyl radical, R3 represents hydrogen or a 1-3C-alkyl or 1-3C-alkoxy radical, R4 represents hydrogen or a 1-3C-alkyl radical and n represents the number 0 or 1, and their salts are new compounds with a marked protective effect on the stomach.

Substituted thienobenzodiazepinones of the general formula I ##STR1## [wherein R.sup.1 denotes a hydrogen atom (--H) or an alkyl radical with 1 to 4 carbon atoms; R.sup.2 represents a halogen atom (halo) or has one of the meanings of R.sup.1 ; R.sup.3 denotes a halogen atom (halo) or the group --N(R.sup.4)R.sup.5 ; R.sup.4 denotes an alkyl radical with 1 to 4 carbon atoms or an alkenyl radical with 3 to 5 carbon atoms; R.sup.5 has one of the meanings of R.sup.4 or represents the group --(CH.sub.2).sub.m --N(R.sup.6)R.sup.7 ; or R.sup.4 and R.sup.5, together with the nitrogen atom to which both are bonded, denote a morpholino group, a pyrrolidino group, a piperidino group, a hexahydroazepin-1-yl group, a piperazin-1-yl group (which is optionally substituted in the 4-position by a methyl, ethyl or benzyl group), a 2,4-dimethylpiperazin-1-yl group, or a hexahydro-1H-1,4-diazepin-1-yl group (which is substituted in the 4-position by a methyl or ethyl group); R.sup.6 denotes an alkyl group with 1 to 4 carbon atoms; R.sup.7 denotes an alkyl group with 1 to 4 carbon atoms; A denotes a straight-chain or branched alkylene group with 1 to 5 carbon atoms; and m denotes 2 or 3] and their acid-addition salts are new compounds. They either have a protective action on the stomach and intestine and are suitable for treating illnesses based on disorders of the stomach or intestine, or they are intermediates for preparing products having protective action. Processes for the preparation of the new pharmacologically-active compounds and of the intermediate products are presented.

Substituted tricyclic thieno compounds, their synthesis, their use,

Pyrazol-4-acetic acid compounds, such as substituted pyrazol-4-acetic acid, its esters, amides, nitriles and their pharmaceutically acceptable salts and method for the preparation of these compounds are disclosed. The novel compounds are useful analgesics, anti-inflammatory, and antipyretics.

Pharmaceutical compositions comprising a pyrazole derivative and method

1-(Lower)alkyl-4-(substituted)aminoalkylcarbonyl-1,4,9,10-tetrahydropyrazol o[4,3-b][1,5]benzodiazepin-10-ones are useful, e.g., to protect warm blooded animals against the formation of gastric ulcers. They are active ingredients in otherwise conventional medicament compositions administered enterally or parenterally in standard dosage forms. Their synthesis, their novel intermediates and their acid-addition salts are described.

Pyrazolobenzodiazepinones, their intermediates, their compositions and

Pyrazol-1-ylphenylacetic acids of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are the same or different and denote a hydrogen atom or a halogen atom,

Pyrazol-1-ylphenylacetic acids

Pyrazol-4-acetic acid compounds, such as substituted pyrazol-4-acetic acid, its esters, amides, nitriles and their pharamaceutically acceptable salts and method for the preparation of these compounds are disclosed. The novel compounds are useful analgesics, anti-inflammatory, and antipyretics.

Pyrazol-4-acetic acid compounds

3-(5-Nitro-2-furyl)pyrazoles unsubstituted in the 5-position and 5-(5-nitro-2-furyl)pyrazoles unsubstituted in the 3-position are antimicrobials and disinfectants. The compounds are structurally represented by one of the formulae: ##STR1## wherein A is --CHO, --CN, --COOH, a protected or derived aldehyde group or a protected or derived carboxylic acid group;

(Nitrofuryl)pyrazoles, their synthesis and use, and compositions

1,3-Diaryl-5-halogen-pyrazole-4-acetic acids and their derivatives with analgetic, antipyretic and antiphlogistic action are described.

Growing community of inventors

Constance, Germany

Georg Rainer