Charité – Universitätsmedizin Berlin

Harvard College

Depuy Synthes Products, Inc.

Synthes USA, LLC

Karl Storz-Gmbh & Co. Kg

Pluristem Ltd.

Charite - Universitaetsmedizin Berlin

Haase Investments Ug

Matricel Gmbh

Georg N Duda

David J Mooney

Markus Hehli

Hans-Dieter Volk

Reto Frei

Markus Heller

Simon Reinke

Katharina Schmidt-Bleek

Sven Geissler

Conor James Walsh

Thomas E Schaus

Herman H Vandenburgh

Ellen T Roche

Michael Fuchs

Carsten Reissner

Patrick Strube

Julia Zimmer

Tobias Winkler

Ingo Heschel

Hans Leemhuis

Georg Matziolis

Aarón Xerach Herrera Martín

Ansgar Petersen

Philipp Von Roth

Uwe Bl&uuml;cher

Pascal Joly

Carsten Perka

Jan Seufert

Stefan Mundlos

Matthias Pumberger

Andrea Sass

Christian Meisel

Christian Kleber

Christine A Cezar

Anke Dienelt

Petra Seemann

Sebastian Wendler

Hanna Schell

Talmoor Hasan Qazi

Provided herein is a method for predicting the probability of having or developing a non-fusion, wherein said method comprises determining the frequency of a subpopulation of CD8+ T cells selected from CD8+CD57+, CD8+CD28&#x2212; and CD8+CD57+CD28&#x2212; in a sample obtained from a patient. Also provided herein is a system for predicting the probability of having or developing a non-fusion.

CD8 T cell subsets as a biomarker for predicting non-fusion after spinal fusion surgery

The present invention relates to a method for diagnosis of delayed bone fracture healing, comprising determining the frequency of a subpopulation of CD8+ cells selected from a first group comprised of CD8+CD57+, CD8+CD28&#x2212; and CD8+CD28&#x2212;/CD57+, in a sample obtained from a subject. The present invention further relates to a system and a kit of parts for prediction and resulting options for preventing of delayed bone fracture healing.

CD8+T-cell subsets as markers for prediction of delayed fracture healing

A biomaterial, particularly for tissue regeneration, includes an open, porous bioresorbable first material portion and a second material portion that is stiffer than the first material portion, wherein the volume fraction of the stiffer material is less than 30% of the total volume of the biomaterial, and the structural stiffness of the second material portion is at least 10 times greater than that of the first material portion.

Biomaterial

The present invention provides methods and compositions for promoting regeneration of a tissue, methods for preventing or reducing inflammation of a tissue, methods for preventing or reducing fibrosis of a tissue, methods for increasing a mass of a tissue, methods for increasing a level of oxygen available to a tissue, methods for increasing a rate of metabolic waste removal from a tissue, methods for increasing blood perfusion to a tissue, and methods of treating severe muscle tissue damage in a subject in need thereof by contacting the tissue with a composition that is suitable for applying cyclic mechanical compression to the tissue.

Compositions and methods of mechanically inducing tissue regeneration

The present invention is directed to a device for enriching cells with a cell surface marker, comprising an aptamer suitable for specifically binding the cell surface marker, and beads coupled thereto, wherein the aptamer is coupled to the beads in a manner that allows for release of cells expressing the cell surface marker, in the absence of a chemical agent, and production of a cell population enriched for cells expressing the cell surface marker, substantially free of beads and aptamer. Kits comprising the device or components thereof, and methods of cell enrichment, are also provided. In exemplary embodiments, the device contains an aptamer that specifically binds CD31.

Compositions and methods for enrichment of cells

The present invention relates to a therapeutic substance and/or medicament and methods relating to the use of said substance and/or medicament for skeletal muscle regeneration using mesenchymal stem cells (MSCs) which can be applied directly or shortly after muscle damage or injury.

Skeletal muscle regeneration using mesenchymal system cells

A component for an arrangement at an implant includes a sensor detecting a measurement variable and generating measuring data corresponding to the detected measurement variable; telemetry device transmitting data; a data transmission connection between the sensor and the telemetry device for the transmission of the measuring data therebetween; and an assembly arrangement detachably mounting the component in an implant recess of the implant wherein the component is configured to be insertable through an implant recess of an implant positioned over a target portion of a bone so that the component extends through the opening toward an outer periphery of the target portion of the bone.

Component and method for assembling an implant arrangement

The present invention is directed to an isolated peptide comprising or consisting of an amino acid sequence with an amino acid identity of at least 90% compared to mature human BMP2 with SEQ ID No. 1, characterized in that said amino acid sequence comprises at least two amino acid substitutions characterized in that a first amino acid substitution occurs at a position corresponding to N59, S88, E94, V99, K101 and/or N102 of SEQ ID No. 1 and to uses thereof.

Bone morphogenetic protein 2 (BMP2) variants with reduced BMP antagonist sensitivity

A guide body is designed to receive longitudinal fixation elements such as wires nails, pegs or screws which are to be anchored within bone. The guide body includes a top surface, a bottom surface, and a number of openings connecting the top surface with the bottom surface. The central axes of at least two of the openings are transverse to each other. The guide body permits the insertion of fixation elements at various angles with respect to each other. The guide body may prevent fixation elements which extend into the intramedullary region or the spongiosa from being displaced either in the proximal or in the distal direction.

Surgical guide body

The invention refers to a component for arrangement at an implant as well as a method for the assembling of an implant arrangement. The component comprises a basic component, at least one sensor arranged in the basic component for the detection of a measurement variable and for the generation of measuring data for the detected measurement variable, a telemetry device arranged in the basic component for transmitting and receiving data and a data transmission connection between the at least one sensor device and the telemetry device for the transmission of data between the at least one sensor device and the telemetry device, whereby the data comprise the measuring data. At the basic component, assembly means for mounting the basic component in an implant recess are formed.

The invention relates to an osteosynthesis implant () that preferably consists of a bioresorbable plastic material. The inventive implant receives the longitudinal fixation elements () to be anchored in the bone, especially in the form of wires, nails, pins or screws. The openings destined to receive the fixation elements () do not completely extend through the implant () like in conventional bone plates or intramedullary nails but are degenerated to indents () in the surface of the implant () so that they may serve as a guide for the fixation elements () to be guided through the implant (). The inventive implant () allows insertion of the fixation elements () in the bone diverging angles and crossing one another, so that the fixation elements () extending intramedullarly or in the spongiosa are primarily prevented from migrating in a proximal or distal direction.

Plastic implant for osteosynthesis

The invention relates to a method and a device for the contact-free determination of the mechanical rigidity of hard, as well as soft biological materials (e.g. articular cartilage) in body cavities (e.g. arthroscopically), using a defined jet of liquid. The distance between the measurement device and the measurement surface (e.g. articulation surface) is continuously measured in a predetermined measurement zone by means of an optical method. The inventive solution is suited for measuring the mechanical rigidity of native cartilage, articular cartilage substitute, cartilage deficiency fillings or of other biological materials, and therefore for the user-independent and fast analysis of the quality of regenerated materials as compared to the native starting material.

Method and device for testing the rigidity of biological tissue

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Berlin, Germany

Georg N Duda