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Georg Maiwald

Thomas Muster

Hermann W Katinger

Gottfried Himmler

Florian Ruker

Franz J Steindl

Martin Purtscher

Alexandra Trkola

This invention concerns peptides binding to antibodies which show neutralizing activity against different strains and clinical isolates of HIV-1 and which inhibit the fusion of cells infected with HIV-1. These peptides are combined with an adjuvant, as recombinant fusion proteins, chemically coupled to carrier molecules, as recombinant chimeric viruses or as recombinant antibodies.

Peptides that induce antibodies which neutralize genetically divergent

The present invention relates to fusion peptides wherein at least one peptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NO: 1 through SEQ ID NO: 25 is bound to an adjuvant being a protein molecule by fusion of the respective nucleotide sequences and subsequent expression of the fusion genes in a biological expression system.

This invention refers to peptides binding to antibodies that show neutralizing activity against different strains and clinical isolates of HIV-1 and that inhibit the fusion of cells caused by HIV-1. These peptides are applied with an adjuvant, as recombinant fusion proteins, chemically coupled to carrier molecules, as recombinant chimeric viruses or as recombinant antibodies.

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Vienna, Austria

Georg Maiwald