Roche Diagnostics Gmbh

Inova Pharma Systems Gmbh

Georg Kallmeyer

Gerhard Winter

Heinrich Woog

Juergen Rothbauer

Bernd Laukenmann

Christian Klessen

Theo Wilfried Arnitz

Michael Nikolaus Mueller

The invention concerns lyophilized pharmaceutical preparations of monoclonal or polyclonal antibodies which contain a sugar or an amino sugar, an amino acid and a surfactant as stabilizers. In addition the invention concerns a process for the production of this stable lyophilizate as well as the use of a sugar or amino sugar, an amino acid and a surfactant as stabilizers for therapeutic or diagnostic agents containing antibodies.

Stable lyophilized pharmaceutical preparations of monoclonal or polyclonal antibodies

In a method and a device for filling needle-free injectors, it is proposed that filling takes place through the injector discharge opening and where the piston stopper has been previously inserted. Filling takes place in such a way that, independently of tolerances of the injector, the interior space is filled to the brim in an at least approximately bubble-free manner. It is not absolutely necessary to measure or dose the liquid to be filled. The filled state is either established through the disappearance of the vacuum in the interior space, or through the piston having reached a specific position during displacement.

Method and device for filling needle-free injectors

Growing community of inventors

Mannheim, Germany

Georg Kallmeyer