Cilag International Gmbh

Mcneil Ab

Georg Feth

Carl Richter

John E Mills

An improved process for preparing fenoctimine, which is 4-(diphenylmethyl)-1-[(octylimino)methyl]piperidine by: (1) reacting dimethylformamide with dimethyl sulfate to form a complex; (2) reacting the resultant dimethylformamide/dimethyl sulfate complex with n-octylamine and optionally with dimethylamine; (3) thereafter treating the reaction with aqueous base to form N,N-dimethyl-N'-octyl-formamidine; and (4) reacting said formamidine, without need for further purification, with 4-(diphenylmethyl) piperidine to obtain 4-(diphenylmethyl)-1-[(octylimino)-methyl]piperidine.

Process for preparation of substituted formamidine and substituted

Compounds of the class of 1-(3-anilinopropyl)-imidazoles oxysubstituted in the 2-position having antimicrobial activity.

1-(2-Oxysubstituted-3-anilinopropyl)-imidazoles

Quaternary N-alkyl pyrazole derivatives and their method of preparation are described. The pyrazole derivatives are useful as antimicrobial agents.

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Schaffhausen, Switzerland

Georg Feth