Boehringer Ingelheim International Gmbh

Boehringer Ingelheim Pharma Gmbh & Co Kg

Georg Dziewas

Juergen Schroeder

Svenja Renner

Burkhard Jaeger

Thomas Fachinger

Thomas Wirth

Carsten Reichel

Tim Baatz

Cartsen Reichel

The invention relates to a method for closed sampling from filling plants comprising the following steps in: The subject matter of the invention is also a sampling device, in particular for carrying out the method.

Method for closed sampling and sampling device

The invention relates to an improved process for preparing aminocrotonylamino-substituted quinazoline derivatives of general formula (I) wherein the groups R, R, Rand Rhave the meanings given in the claims, as well as sulphonyl derivatives of formula and the use thereof as synthesis components for preparing quinazolines of formula (I). The quinazoline derivatives of formula (I) are inhibitors of signal transduction mediated by tyrosinekinases and by the Epidermal Growth Factor-Receptor (EGF-R) and are therefore particularly suitable for the treatment of tumoral diseases.

Process for preparing aminocrotonylamino-substituted quinazoline derivatives

The invention relates to an improved process for preparing aminocrotonylamino-substituted quinazoline derivatives of general formula (I) wherein the groups R, R, Rand Rhave the meanings given in the claims, as well as sulphonyl derivatives of formula (XIII) and the use thereof as synthesis components for preparing quinazolines of formula (I). The quinazoline derivatives of formula (I) are inhibitors of signal transduction mediated by tyrosinekinases and by the Epidermal Growth Factor-Receptor (EGF-R) and are therefore particularly suitable for the treatment of tumoral diseases. 

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Urbar, Germany

Georg Dziewas