Sandoz Gmbh

Georg Bolliger

Hans Kobel

Hans Tscherter

Jean-Jacques Sanglier

Rene Amstutz

Gideon Shapiro

Peter Stutz

Pilocarpine derivatives of formula I, ##STR1## wherein R.sub.1 to R.sub.5 are as defined in the description, are useful in the treatment of senile dementia, Alzheimer's disease, confusional conditions in the elderly, myasthenia gravis, schizophrenia, mania or glaucoma.

Pilocarpine compounds which are used as pharmaceutical agents

Pilocarpine derivatives

9-thia ergot cyclic peptide alkaloids produced by fermentation or synthetic methods have interesting anti-parkinson and other pharmacological activities.

Ergot cyclic peptide alkaloids having a venotonizing effect, useful for

Spiro compounds, comprising a five-membered carbocyclic ring interrupted by two heteroatoms in ring positions 1 and 3 chosen from oxygen and sulfur atoms and in which the carbon atom in ring position 4 is common to a 4 to 8-membered carbocyclic ring interrupted by a nitrogen atom, are useful as pharmaceuticals.

Spiro-dioxolanes, -dithiolanes and -oxothiolanes, and their use in

Use of thio isosteres of ergot peptide alkaloids as vasaconstrictors

A 2-methyl-8 (R) or (S) ergot peptide alkaloid in free base form or in pharmaceutically acceptable acid addition salt form is a useful anti-Parkinson agent, prolactin secretion inhibitor, anti-depressant, vigilance-increasing agent, and anti-migraine agent.

Ergot peptide derivatives, their preparation and pharmaceutical

9-Thia ergot cyclic peptide alkaloids produced by fermentation or synthetic methods have interesting anti-parkinson and other pharmacological activities.

Growing community of inventors

Binningen, Switzerland

Georg Bolliger