Boehringer Ingelheim International Gmbh

Boehringer Ingelheim Pharma Kg

Boehringer Ingelheim Pharma Gmbh & Co Kg

Other

Georg Boeck

Michael Walz

Dieter Hochrainer

Johannes Geser

Ralf Thoemmes

Hubert Hoelz

Christian Scheffler

Christoph Kreher

Burkhard Metzger

Hubert Kunze

Michael Schyra

Guido Schmiedel

Christian Golberg

Birgit Westmeier

Stephen Terence Dunne

Michael Spallek

Joachim Eicher

Herbert Wachtel

Matthias Hausmann

Timo Von Brunn

Andreas Fiol

Florian Witte

Joerg Schiewe

Friedrich Schmidt

Karoline Bechtold-Peters

Jochen Ziegler

Hans-Juergen Koelbel

Christian Feiertag

Christian Goldberg

Ralf Thömmes

Rolf Doerr

Burkhard P Metzger

Rolf Dorr

An atomizer and a method of dispensing and atomizing fluid into individual containers through a nozzle are proposed, where in order to improve the dosing accuracy, a preliminary amount of fluid, flushing the nozzle, is dispensed before each dose is dispensed.

Atomizer and method of atomizing fluid with a nozzle rinsing mechanism

A nebulizer for a fluid, particularly for medical aerosol treatment is proposed. To allow easier operation and confer improved operational reliability a sealed container holding the fluid is already arranged in the nebulizer when it is supplied and the nebulizer is constructed so that the container is opened inside the nebulizer before or during the first use of the nebulizer. Alternatively, or in addition, the nebulizer is constructed so that the container cannot be replaced, and in particular, cannot be removed.

Nebulizer

An atomizer for a fluid, in particular, a fluid for medical aerosol therapy. In order to allow simplified operation and improved safety in use, the atomizer has a counter device for counting the number of operations of the atomizer and the number of containers inserted. The atomizer is locked against further operation and/or against removal of the current container or insertion of a new container, if a certain number of operations of the atomizer and/or a certain number of containers inserted has/have been reached or exceeded.

Atomizer

A process and a device for dosing a pharmaceutical agent, preferably a liquid, are proposed. To achieve an enhanced dosing accuracy, a first component that is produced in batches, such as a shaped seal, is combined with a second component, such as a guide pipe selected from a suitable group guide pipes, wherein the suitable group of second components is selected based on at least one decisively significant value of the respective batch first components and is distinguished by an essential value of the second component which will optimize the sealing between the first and second components.

Process and device for dosing pharmaceutical agents

The invention relates to a powder inhaler () with mouthpiece () for dispersing pharmaceutical medicament formulations, which comprises an auxiliary energy source in the form of a pressure medium system (), having a device for supplying () a powder formulation (), while on activation of the pressure medium system a gaseous pressure medium () released by the pressure medium system () forms an aerosol () with the powder formulation () such that the powder particles are present in the gaseous pressure medium () in dispersed form. This is achieved by means of a powder inhaler () comprising a multi-channel nozzle, the channels of which are inclined to one another at an angle such that the aerosol jets flowing through them meet one another downstream behind the nozzle ().

Powder inhaler having a nozzle with a plurality of channels

Propellant gas inhaler fitted with a valve or valve system through which at least two clouds of aerosols or at least two jet streams are produced that travel towards one another at an angle from 0&#xb0; to 180&#xb0;, so that the individual aerosol particles at least partially impact with one another and lose kinetic energy thereby.

Impaction nozzle for propellant driven metered dose aerosols

An inhaler for administering a medicament in the form of inhalable substances, formulations or mixtures of substances comprises a housing () having an inner cavity for holding the medicament, which is coupled to a mouthpiece (). The housing () is rigidly connected to the mouthpiece ().

Inhaler

A pharmaceutical composition comprising: wherein Xis an anion;

Aerosol formulation for inhalation comprising an anticholinergic

The measurement of the particle size distribution of an aerosol is of crucial importance in pharmaceutical development. A prerequisite for this is a valid method, e.g. the cascade impactor method described in the pharmacopoeias. It requires measurement of the active substance concentration in order to determine the particle size distribution. The invention provides a process which makes it possible to measure the size of aerosol droplets containing pharmaceutical substances which are unstable in the event of changes in the pH.

Process for determining the particle size distribution of an aerosol and apparatus for carrying out such a process

Disclosed herein are methods for measuring the particle size distribution of a pharmaceutical aerosol, including methods utilizing laser diffraction.

Measuring particle size distribution in pharmaceutical aerosols

The invention relates to a new process for producing powdered preparations for inhalation comprising a substance having a smaller particle size distribution and a substance having a larger particle size distribution, wherein a substance having a smaller particle size distribution and a substance having a larger particle size distribution are continuously metered into a suitable mixing container such that the quotient N of the delivery speed for the metering of the substance having the smaller particle size distribution and the delivery speed for the metering of the substance having the larger particle size distribution is at least as great as the quotient M of the total mass of the substance having the smaller particle size distribution and the total mass of the substance having the larger particle size distribution.

Process for preparing inhalable powders

The invention relates to powdered preparations containing tiotropium for inhalation, processes for preparing them as well as their use in preparing a pharmaceutical composition for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.

Inhalable powder containing tiotropium

The invention relates to a new process for producing powdered preparations for inhalation.

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Laupheim, Germany

Georg Boeck