Commonwealth Scientific and Industrial Research Organisation

Peptide Technology Limited

Geoffrey W Grigg

Wolfgang H Sasse

Deborah Ann Rathjen

Fred Widmer

Desmond J Brown

Philip O Mack

Peptide which abrogates TNF and/or LPS toxicity

The use of various polycyclic nitrogen-containing compounds, such as triphenylmethane dyes to potentiate the bioactivity of antibiotics of the phleomycin series.

Antibiotic mixtures

Purines useful for the potentiation of antibiotics, particularly phleomycin and bleomycin, have the general formula: ##STR1## wherein W is selected from the group consisting of --SRCONR.sup.1 R.sup.2, --SRCN, and --SRCOR.sup.1, in which R is a --(CH.sub.2).sub.n -- group (n is an integer of 1 to 5) which may bear one or more side chain alkyl groups each having from 1 to 5 carbon atoms, and R.sup.1 and R.sup.2, which may be the same or different, are selected from hydrogen atoms and straight or branched chain alkyl groups having from 1 to 5 carbon atoms, or alternatively, R.sup.1 and R.sup.2 together comprise a polymethylene, oxapolymethylene or thiapolymethylene chain containing from 4 to 10 carbon atoms;

Purines useful for the potentiation of antibiotics

Growing community of inventors

Sydney, Australia

Geoffrey W Grigg