Indigo Ag, Inc.

Seres Therapeutics, Inc.

Axcella Health Inc.

Kaleido Biosciences, Inc.

Indigo Agriculture, Inc.

Massachusetts Institute of Technology

Ait Austrian Institute of Technology Gmbh

Flagship Pioneering Innovations V, Inc.

Dsm Nutritional Products Inc.

Symbiota, Inc.

Seres Health, Inc.

Pronutria, Inc.

Children's Medical Center Corporation

Flagship Pioneering Innovations Vi, LLC

Sana Biotechnology, Inc.

Geoffrey Von Maltzahn

David Arthur Berry

Slavica Djonovic

Luis Miguel Marquez

David Morris Johnston

Craig Sadowski

Richard Bailey Flavell

Jeffrey Lyford

Matthew R Henn

Alexander Naydich

Noubar Boghos Afeyan

Brett Adam Boghigian

John Miles Milwid

Anthony Mario D'Onofrio

Phillip Samayoa

Karen V Ambrose

Jared Silverman

Brian Goodman

Sangeeta N Bhatia

Richard A Flavell

Gerardo Vicente Toledo

Yves Alain Millet

David N Cook

John Grant Aunins

Kevin Daniel Litcofsky

John M Geremia

Jacob Rosenblum Rubens

Nathaniel Silver

Yvonne J Yamanaka

Michael Hamill

Mary-Jane Lombardo McKenzie

Jonathan W Leff

Marin Vulic

Gregory McKenzie

Eric Michael Jeck

Barry Loyd Knight

Rachel Ariel Raymond

Jonathan Winkler

Neal Hitesh Rajdev

Robert Berendes

Jonathan Hennek

David Patrick Perry

Rajeev Chillakuru

John Kramarczyk

Xuecheng Zhang

Gabriel A Kwong

Birgit Mitter

Angela Sessitsch

Paul Andrew Gray

Muhammad Naveed

Mary-Jane Lombardo Mckenzie

Nathan Post

Teresa Berninger

Stephane Compant

Toshiro Kendrick Ohsumi

Michael Travis Mee

David Weisman

Ean Shaughnessy Wahl Mullins

Charles David Brummitt

Jyoti Shankar

Kyle Marvin Trudeau

Carlos Becco

Daniel Bachner

Justin Y H Wong

Marc-Cedric Joseph Meunier

Kiana Mahdaviani

Casey James Leist

Pranav Ram Tadi

David Young

Andrea Lee Flaherty

Philip Gabriel Sheets-Poling

Naveen Neil Sinha

Rodney Connor

Jordan Lambert

Mark Allen

Allison Jack

Fernando Derossi

Ewan Lamont

Trudi A Gulick

Rob Lowenthal

Molly Krisann Gibson

Dan Creagh

Steve Abramson

Ben Allen

Chris Moscardini

Jeremy Crane

William Pate

Subhayu Basu

Gerard Keating

Barrett Ethan Steinberg

Robert James Citorik

Shaila Rahman

James D McCully

William Edward Salomon

Neal Gordon

Douglas B Cowan

Michael Doherty

Nathan Wilson Stebbins

Gerardo V Toledo

Han Zhang

This application relates to methods and materials for providing a benefit to a seed or seedling of an agricultural plant (e.g., an agricultural grass plant), or the agricultural plant derived from the seed or seedling. For example, this application provides purified bacterial populations that include novel seed-origin bacterial endophytes, and synthetic combinations of seeds and/or seedlings (e.g., cereal seeds and/or seedlings) with heterologous seed-derived bacterial endophytes.

Methods of use of seed-origin endophyte populations

Provided are therapeutic compositions containing microbial populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.

Synergistic bacterial compositions and methods of production and use thereof

Methods and compositions for modulating a target genome are disclosed. The composition may comprise a first RNA encoding a polypeptide comprising a retrotransposase reverse transcriptase domain and a retrotransposase endonuclease domain. The composition may also comprise a second RNA comprising a sequence that binds the polypeptide and a heterologous object sequence. The composition may insert the sequence of the heterologous object sequence into a target DNA.

Methods and compositions for modulating a genome

The present disclosure provides, at least in part, methods and compositions for in vivo fusosome delivery. In some embodiments, the fusosome comprises a combination of elements that promote specificity for target cells, e.g., one or more of a fusogen, a positive target cell-specific regulatory element, and a non-target cell-specific regulatory element. In some embodiments, the fusosome comprises one or more modifications that decrease an immune response against the fusosome.

Fusosome compositions and uses thereof

Preparations of glycan therapeutics, pharmaceutical compositions, dietary supplements and medical foods thereof are provided, and methods of using said gycan therapeutics, e.g. in cancer therapy.

Glycan therapeutic compositions and related methods thereof

The disclosure provides, for example, single stranded, covalently closed DNA that does not form a double stranded structure longer than 100 base pairs. The ssDNA may encode an effector sequence, for instance a therapeutic protein. The ssDNA may comprise a nuclear targeting sequence (NTS). In some embodiments, the ssDNA shows decreased activation of the innate immune system compared to an otherwise similar dsDNA.

DNA compositions and related methods

A crop prediction system performs various machine learning operations to predict crop production and to identify a set of farming operations that, if performed, optimize crop production. The crop prediction system uses crop prediction models trained using various machine learning operations based on geographic and agronomic information. Responsive to receiving a request from a grower, the crop prediction system can access information representation of a portion of land corresponding to the request, such as the location of the land and corresponding weather conditions and soil composition. The crop prediction system applies one or more crop prediction models to the access information to predict a crop production and identify an optimized set of farming operations for the grower to perform.

Machine learning in agricultural planting, growing, and harvesting contexts

Compositions, e.g., pharmaceutical compositions, nutritional compositions, medical foods, and food ingredients, as well as their methods of use, are provided, for treating diseases associated with hyperammonemia, e.g., urea cycle disorders (UCD) and hepatic encephalopathy (HE), e.g., minimal HE (MHE) and overt HE (OHE), and modulating enzyme activities and levels of microbes and taxa, and metabolites (e.g., ammonia) in the microbiome of a subject.

Glucose glycans for treating urea cycle disorders

Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.

An online agricultural system manages and optimizes interactions of entities within the system to enable the execution of transaction and the transportation of crop products. The online agricultural system accesses historic and environmental data describing factors that may impact crop product transactions and/or transportation to determine market prices for crop products and crop product transportation. Responsive to receiving a request from an entity, the online agricultural system determines an optimal transaction for the entity, such as a price for selling a crop product, an available crop product for purchase, or a transportation opportunity to transport a crop product.

Interaction management in an online agricultural system

Therapeutic chondrisome and mitoplast compositions and related methods are described.

Methods and compositions relating to chondrisomes from blood products

Therapeutic chondrisome compositions and related methods are described.

Methods and compositions relating to chondrisomes from cultured cells

Preparations of glycan therapeutics, pharmaceutical compositions, dietary supplements and medical foods thereof are provided, and methods of using said glycan therapeutics, e.g. in cancer therapy.

Growing community of inventors

Boston, MA, United States of America

Geoffrey Von Maltzahn