Smith Kline & French Laboratories Limited

Geoffrey R Owen

Graham J Durant

Charon R Ganellin

Rodney C Young

The compounds are novel N-substituted-N'-heterocyclic alkylthioureas, guanidines and 1-nitro-2,2-diaminoethylene compounds which are histamine H.sub.2 -antagonists.

Azolyl alkylthioureas and guanidines alkylaminonitroethylene compounds

Pyridyl alkylthiourea and alkylamino-nitroethylene

Blocking histamine H.sub.2 -receptors with imidazolylalkyl guanidine

Imidazole alkylthiourea compounds

Pyridyl alkylguanidines

Imidazolyl alkylamino nitroethylene compounds

Thiazole and isothiazole derivative as blockers of histamine H.sub.2

The compounds are N-oxy and N-amino guanidines which are histamine H.sub.2 -antagonists. A compound of this invention is N-hydroxy-N'-methyl-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidi ne.

N-oxy and N-amino guanidines

Imidazolyl alkylguanidine compounds

N-Oxy and N-amino guanidines

The compounds are N-oxy and N-amino guanidines which are histamine H.sub.2 -antagonists. A compound of this invention is N-hydroxy-N'methyl-N'-[2-((4-methyl-5-imidazolyl)methylthio)-ethyl]guanidi ne.

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High Wycombe, United Kingdom

Geoffrey R Owen