Cancer Research Campaign Technology Limited

Geoffrey Paul Margison

Joseph Anthony Rafferty

Amanda Jean Watson

Jane Kelly

Rhoderick Hugh Elder

Thomas Brian McMurry

Dorothy Josephine Donnelly

Mark Andrew Willington

Robert Stanley McElhinney

Joan Elizabeth McCormick

Paul Murray

Christophe Carola

Edward Stuart Newlands

Mark Ross Middleton

Robert Stanley McBlhinney

John Colin Baer

Azadeh Alison Freeman

The present invention provides certain 6-hetarylalkyloxy pyrimidine derivatives of formula II ##STR1## wherein R is (i) a cyclic group having at least one 5- or 6-membered heterocyclic ring, optionally with a carbocyclic or heterocyclic ring fused thereto, the or each heterocyclic ring having at least one hetero atom chosen from O, N, or S, or a substituted derivative thereof; or (ii) phenyl or a substituted derivative thereof,

Pyrimidine derivatives and guanine derivatives, and their use in

O.sup.6 -hetarylalkyl- or naphthylalkylguanine derivatives of the formula ##STR1## wherein Y is H, ribosyl, deoxyribosyl, or R'XCHR',

O.sup.6 -substituted guanine derivatives, a process for their

The present invention provides certain 6-hetarylalkyloxy pyrimidine derivatives of formula II ##STR1## wherein R is (i) a cyclic group having at least one 5- or 6-membered heterocyclic ring, optionally with a carbocyclic or heterocyclic ring fused thereto, the or each heterocyclic ring having at least one hetero atom chosen from O, N, or S, or a substituted derivative thereof; or (ii) phenyl or a substituted derivative thereof, R.sup.2 is selected from H, C.sub.1 -C.sub.5 alkyl, halogen or NH.sub.2, R.sup.4 and R.sup.5 which are the same or different are selected from H, NH.sub.2 or NO.sub.n where n=1 or 2, or R.sup.4 and R.sup.5 together with the pyrimidine ring form a 5-or 6-membered ring structure containing one or more heterocyclic atoms, and pharmaceutically acceptable salts thereof, exhibit the ability to deplete O.sup.6 -alkylguanine-DNA alkyltransferase (ATase) activity.

Pyrimidine and purine derivatives and their use in treating tumour cells

Potentiation of temozolomide in human tumour cells

Growing community of inventors

Poynton, United Kingdom

Geoffrey Paul Margison