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Sky High, LLC

Geoffrey Collins

Winston Wicomb

Ian C Bathurst

Matthew W Foehr

A composition comprising a storage-stable organ preservation solution, comprising a linear polyethylene glycol having an average molecular weight of approximately 20,000 Daltons and being essentially free of decomposition products. This solution can be used for organ preservation as a perfusate in a process in which the perfusate is flowed through the circulatory system of the organ, and can also be used for transplantation or routine open heart cardioplegic applications. The composition can be contained in a system comprising a means for preventing light exposure, especially UV light, to the solution. In addition, the system is preferably impervious to gases, particularly oxygen.

System for storing polyethylene glycol solutions

An organ preservation solution, particularly valuable in the preservation of mammalian hearts intended for transplantation, in aqueous solution, at least about 3% by weight of polypropylene glycol having an average molecular weight of at least about 15,000 daltons and being free of material retained by 10 micron filtration, a buffer buffering the pH of the solution perfusate to a value in the range of about 7.1 to about 7.5, and an impermeant composition for retarding the passage of water across cell membranes of an organ treated with the solution.

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Belvedere, CA, United States of America

Geoffrey Collins