Solazyme, Inc.

Arch Personal Care Products L.p.

Corbion Biotech, Inc.

Terravia Holdings, Inc.

Algenist Holdings, Inc.

Geoffrey Brooks Consultants, LLC

Botaneco Inc.

Geoffrey Brooks

Scott Franklin

Anthony G Day

Aravind Somanchi

James Vincent Gruber

Smitha Rao

Jeff Avila

Walter Gregory Rakitsky

John Piechocki

Stephen M Decker

Leslie M Norris

Enrique Baliu

Anna Coragliotti

Rajendra Sahai Bhatnagar

Andrew P Banham

Shuanghui Liu

Dana Zdanis

Soo In Yang

Yves Lanctot

Lesile M Norris

The invention provides novel microalgal food compositions comprising microalgal biomass that have been processed into flakes, powders and flours. The microalgal biomass of the invention is low in saturated fats, high in monounsaturated triglyceride oil and can be a good source of fiber. The invention also comprises microalgal biomass that is suitable as a vegetarian protein source and also as a good source of fiber. Novel methods of formulating food compositions with the microalgal biomass of the invention are also disclosed herein including beverages, baked goods, egg products, reduced fat foods and gluten-free foods. The provision of food compositions incorporating the microalgal biomass of the invention to a human have the further benefit of providing healthful ingredients while achieving levels of satiety sufficient to reduce further caloric intake. The invention also provides novel strains of microalgae that have been subject to non-transgenic methods of mutation sufficient to reduce the coloration of the biomass produced by the strains. Oil from the microalgal biomass can be extracted and is an edible oil that is heart-healthy. The novel microalgal biomass and oil therefrom can be manufactured from edible and inedible heterotrophic fermentation feedstocks, including corn starch, sugar cane, glycerol, and depolymerized cellulose that are purpose-grown or byproducts of existing agricultural processes from an extremely broad diversity of geographic regions.

Microalgal food compositions

Methods for making an oleosome-based sunscreen formulation are provided. The methods involve preparing an oleosome suspension buffered at a pH in a range from about pH 3 to about pH 6, and contacting the oleosome formulation with a sunscreen active agent to prepare a sunscreen formulation. The sunscreen formulation may be used to prepare personal care products capable of protecting human skin against ultraviolet radiation. Related compositions are also provided.

Sunscreen formulations comprising an oleosome suspension and an acidic buffering system

Compositions of microalgae-derived flour are disclosed from multiple genera, species, and strains of edible microalgae. Microalgae used in the invention are free of algal toxins and contain varying levels of primarily monounsaturated triglyceride oil. Flours disclosed herein are formulated as free flowing blendable powders, mixed food ingredients, oxidation stabilized, homogenized and micronized, and combinations therein. Flours disclosed herein also form self stabilizing emulsions in slurries with manageable viscosities. Innovative methods of formulating flours and incorporating them into food compositions are also disclosed. The invention also comprises flours with significant digestible protein and unique dietary fiber content and associated water binding, texturizing, and healthy oil delivery attributes. Novel methods of oil and fat replacement using flours of the invention are also disclosed. Flours of the invention can be manufactured from edible and inedible heterotrophic fermentation feedstocks, including corn starch, sugar cane, glycerol, and depolymerized cellulose.

Microalgal flour

Provided herein are microalgal skin care compositions and methods of improving the health and appearance of skin. Also provided are methods of using polysaccharides for applications such as topical personal care products, cosmetics, and wrinkle reduction compositions. The invention also provides novel decolorized microalgal compositions useful for improving the health and appearance of skin. The invention also includes insoluble polysaccharide particles for application to human skin.

Compositions for improving the health and appearance of skin

A novel NF-&#x3ba;B-inhibitor peptide is a component in a skin care composition comprising the NF-&#x3ba;B-inhibitor and a dermatologically acceptable carrier. The composition may also include at least one additional skin care active. Additionally, the composition may include a peptide that acts as a TGF-&#x3b2;1 mimic. Means for treating mature, languished skin with compositions comprising the peptide are also provided.

NF-&#x3ba;B inhibitor composition for skin health

A method of producing yeast-polyphenol ferment extract includes growing the cells of a yeast ofgenus in a growth media to late-logarithmic growth phase, in which the carbon source in the media is exhausted; exposing the cells to a non-cytotoxic dose of polyphenol; and extracting cytoplasmic and extra-cellular components of the exposed yeast cells from the growth media.

Personal care composition containing yeast/polyphenol ferment extract

The invention provides cosmetic compositions comprising microalgal biomass, whole microalgal cells, and/or microalgal oil in combination with one or more other cosmetic ingredients, and methods of making such compositions. In preferred embodiments, the microalgal components of the cosmetic compositions are derived from microalgal cultures grown heterotrophically and which comprise at least 10% oil by dry weight.

Cosmetic compositions comprising microalgal components

Disclosed is a yeast/polyphenol ferment extract, and a personal care composition including the yeast/polyphenol ferment extract. Also disclosed is a method for preparing and using the yeast/polyphenol extract and the personal care composition.

Provided are methods for preparing chemically modified lipids. The lipids are obtained from heterotrophically cultured microalgae and are subjected to a transesterification or interesterification reaction. The microalgae include those from the genus, or strains having at least 85% nucleotide sequence identity in 23S rRNA sequences to a, orstrain that are cultured in a bioreactor substantially in the absence of light.

Modified lipids produced from oil-bearing microbial biomass and oils

Provided are methods for preparing chemically modified lipids. The lipids are obtained from heterotrophically cultured microalgae and are subjected to an epoxidation reaction. The microalgae include those from the genus, or strains having at least 85% nucleotide sequence identity in 23S rRNA sequences to a, orstrain that are cultured in a bioreactor substantially in the absence of light.

Methods for modifying a microalgal lipid by subjecting the lipid to a chemical reaction are provided, the lipid containing no more than 500 ppm color-generating impurities and obtained from, ormicroalgal strains, or strains having at least 85% nucleotide sequence identity in 23S rRNA sequences to such strains grown under heterotrophic conditions.

Growing community of inventors

Reno, NV, United States of America

Geoffrey Brooks