Syntex (u.s.a.) Inc.

Nugen Technologies, Inc.

Geoffrey A Dafforn

Nurith Kurn

Edwin F Ullman

Martin J Becker

The invention relates to methods for analysis of nucleic acid methylation status, and fragmentation and/or labeling and/or immobilization of nucleic acids. More particularly, the invention relates to methods for fragmentation and/or labeling and/or immobilization of nucleic acids comprising labeling and/or cleavage and/or immobilization at abasic sites.

Methods for analysis of nucleic acid methylation status and methods for fragmentation, labeling and immobilization of nucleic acids

A device is disclosed for conducting an assay. The device comprises a housing, means enclosed in the housing for capturing a first member of a specific binding pair (sbp) in a zone and for allowing liquid to be transported by capillary action away from the zone, first means in the housing for introducing the sample into the device, and second means in the housing other than the first means for introducing a liquid reagent other than the sample into the device. The device of the invention finds use in assay methods for the determination of an analyte in a sample suspected of containing the analyte. Kits for conducting an assay are also disclosed.

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Los Altos, CA, United States of America

Geoffrey A Dafforn