Tianjin Fusogen Biotech Co., Ltd.

Tianjin Medical University

Fusogen Pharmaceuticals, Inc.

Wang, Wei

Genfa Zhou

Wangni Tian

Wei Wang

Shumei Xu

Dan Ju

Qing Liang

Pharmaceutical compositions for the prophylaxis and treatment of HIV infection and its use are provided. Particularly, the present invention provides a pharmaceutical composition comprising anti-virus peptides, use of said composition for manufacturing a medicament for the prophylaxis and treatment of HIV infection, and method for preventing and treating HIV infection by using said composition.

Pharmaceutical composition for the prophylaxis and treatment of HIV infection and its use

Provided are &#x3b2;-sheet breaker peptides binding to &#x3b2; amyloid peptide (A&#x3b2;1-42), which have the homologous sequence with A&#x3b2; 14-23. &#x3b2;-sheet breaker peptides can be used for the manufacture of a medicament for prophylactic and/or therapeutic treatment of Alzheimer's Disease.

Beta sheet inhibiting peptides for preventing and/or treating Alzheimer's Disease

A fusion inhibitor used to treat HIV infection, has an amino acid sequence as follows:X-SWETWEREIENYTKQIYKILEESQEQQDRNEKDLLE-Z,wherein X is either an amino group or -X1-X2, wherein X1 is an imino group, and X2 is either an acetyl group, a hydrophobic group, or a macromolecular carrier group; Z is a carboxyl group or -Z1-Z2, wherein Z1 is a carbonyl group, and Z2 is either an amino group, a tert-butyloxycarbonyl group, a hydrophobic group, or a macromolecular carrier group. This inhibitor has strong inhibitory activity against HIV infection.

Pharmaceutical used for treating HIV infection, the composition and uses thereof

A pharmaceutical being used for treating HIV infection is provided which has the following peptide sequence: X-SWETWEREIENYTKQIYKILEESQQDRN-EKDRNEKDLLE-Z, where S is Serine, W is Trytophan, E is Glutamate, T is Threonine, R is Argine, I is Isoleucine, N is Asparagine, Y is Tyrosine, K is Lysine, Q is Glutamine, L is Leucine, D is Aspartic acid, X is amino group, acetyl-hydrophobic group, or macromolecule carrier group, Z is carboxyl group, amino group, amido group, tert-nutyloxycarbonyl group, hydrophobic group, or macromolecule carrier group. The drug inhibits strongly the infection of HIV.

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Tianjin, China

Genfa Zhou