Roussel Uclaf

Genevieve Azadian

Andre Pierdet

Daniel Philibert

Novel 17.alpha.-aryl-steroids of the formula ##STR1## wherein R.sub.1 is alkyl of 1 to 3 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 12 carbon atoms and acyl of an organic carboxylic acid of 1 to 18 carbon atoms, R.sub.3 is aryl of 6 to 12 carbon atoms optionally substituted with at least one substituent selected from the group consisting of --OH, halogen, alkoxy and alkyl of 1 to 4 carbon atoms and --CF.sub.3, the dotted line in the B ring indicating an optional double bond in the 9(10)-position, and A and B are hydrogen and when there is a double bond in the 9(10)-position, A and B form a double bond in the 11(12) position or B is hydrogen and A is an 11.beta.-hydroxy having progestomimetic activity activity without androgenic activity and a process for their preparation and novel intermediates produced therein.

Novel 17.alpha.-aryl-steroids

Anabolisant-androgenic compositions comprising an effective amount of 17.beta.-n-amyloxy-.DELTA..sup.4,9,11 -estratriene-3-one and a pharmaceutical carrier and to a novel method of inducing androgenic and anabolisant activity in humans and other warm-blooded animals by administration of an effective amount of 17.beta.-n-amyloxy-.DELTA..sup.4,9,11 -estratriene-3-one.

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Paris, France

Genevieve Azadian