Othair Prothena Limited

Prothena Biosciences Limited

Gene Kinney

Wagner Marcelo Zago

Robin McDaid Barbour

Tarlochan S Nijjar

Carol Karp

Radhika Tripuraneni

Theresa Anne Neumann

Daniel Keith Ness

The disclosure provides peptide compositions and immunotherapy compositions comprising an amyloid-beta (Aβ) peptide and a tau peptide. The disclosure also provides methods of treating or effecting prophylaxis of Alzheimer's disease or other diseases with beta-amyloid deposition in a subject, including methods of clearing deposits, inhibiting or reducing aggregation of Aβ and/or tau, blocking the uptake by neurons, clearing amyloid, and inhibiting propagation of tau seeds in a subject having or at risk of developing Alzheimer's disease or other diseases containing tau and/or amyloid-beta accumulations. The methods include administering to such patients the compositions comprising an amyloid-beta (Aβ) peptide and a tau peptide.

Multi-epitope vaccine for the treatment of Alzheimer's disease

Antibody formulations and methods useful for treatment of patients with AL amyloidosis.

Methods of treating AL amyloidosis

The invention provides methods of monitoring immunotherapy directed against alpha-synuclein by comparing a subject's constipation symptoms before treatment and at one or more times during and/or after treatment. The immunotherapeutic regime can be monitored depending on the results of treatment.

Monitoring immunotherapy of Lewy body disease from constipation symptoms

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Boca Raton, FL, United States of America

Gene Kinney