Other

Merckle Gmbh

C-a-i-r Biosciences Gmbh

Gene Kim

Michael W Burnet

Jan-Hinrich Guse

Hans-Jurgen Gutke

Michael Wolff

Albert Beck

Georgia Tsotsou

Irina Droste-Borel

Laurence Barker

Jeannette Reichert

Kattie Luyten

Maximilian Busch

Moussa Khobzaoui

Simona Margutti

Thomas Meindl

This invention features a method of identifying a compound useful for enhancing efficacy of a therapeutic agent. The method includes incubating a compound in blood cells; separating immune cells from erythrocytic cells; and determining the ratio of the concentration of the compound in the immune cells to the concentration of the compound in the erythrocytic cells; wherein the compound comprises a transportophore and a therapeutic agent, in which the transportophore is covalently bonded to the therapeutic agent via a bond or a linker.

Method of identifying improved conjugates of biologically active compounds

This invention features a compound of the following formula:T-(-L-C), T is a transportophore, L is a bond or a linker having a molecular weight up to 240 dalton, C is a non-antibiotic therapeutic agent, and m is 1, 2, 3, 4, 5, 6, 7, or 8, in which the transportophore has an immune selectivity ratio of at least 2, the transportophore is covalently bonded to the non-antibiotic therapeutic agent via the bond or the linker, and the compound has an immune selectivity ratio of at least 2.

Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof

This invention features a compound of the following formula: wherein T is a transportophore, L is a bond or linker, and C is an antibiotic therapeutic agent, the transportophore is covalently bonded to the antibiotic therapeutic agent via the bond or the linker, and the transportophore is an azithromycin derivative or crown ether derivative.

Antibiotic conjugates

Growing community of inventors

Tubingen, Germany

Gene Kim