Kowa Company Limited

Gen Watanabe

Junya Tagashira

Toshiharu Morimoto

Tadaaki Ohgiya

Hiroyuki Ishiwata

Takahiro Kitamura

Takeshi Doi

Masanori Ashikawa

Tatsuaki Nishiyama

Syunji Takemura

Satoshi Goda

Masaki Yamabi

Akiyasu Koketsu

Toru Miura

Seiichi Sato

Noriyuki Inoue

Kazuhiro Onogi

Hitomi Aoki

Ryohei Sekimoto

Rie Ishida

Tomoaki Koshizawa

Nao Yamasaki

Disclosed is a compound which has a low molecular weight and has an activity of enhancing the production of EPO and/or an activity of enhancing the production of hemoglobin. Specifically disclosed is and EPO production enhancer and/or a hemoglobin production enhancer comprising a 1-acyl-4-(substituted oxy, substituted amino, or substituted thio)-1,2,3,4-tetrahydroquinoline derivative, more specifically a tetrahydroquinoline compound represented by general formula (1) [wherein R, R, R, Rand Rindependently represent a hydrogen atom, a Calkyl group, or the like; R, R, R, R, R, Rand Rindependently represent a hydrogen atom, a halogen atom, a Calkyl group, or the like; A represents N&#x2014;R, a sulfur atom, or an oxygen atom; Rrepresents a hydrogen atom, a Calkyl group, or the like; B represents a Caryl group, or a 5- to 10-membered heterocyclic group; and n represents an integer of 0 or 1], a salt of the tetrahydroquinoline compound, or a solvate of the tetrahydroquinoline compound or the salt.

Prophylactic and/or therapeutic agent for anemia comprising tetrahydroquinoline compound as active ingredient

Disclosed is a compound which has a low molecular weight and has an activity of enhancing the production of EPO and/or an activity of enhancing the production of hemoglobin. Specifically disclosed is and EPO production enhancer and/or a hemoglobin production enhancer comprising a 1-acyl-4-(substituted oxy, substituted amino, or substituted thio)-1,2,3,4-tetrahydroquinoline derivative, more specifically a tetrahydroquinoline compound represented by general formula (1) [wherein R, R, R, Rand R' independently represent a hydrogen atom, a Calkyl group, or the like; R, R, R, R, R, Rand Rindependently represent a hydrogen atom, a halogen atom, a Calkyl group, or the like; A represents N&#x2014;R, a sulfur atom, or an oxygen atom; Rrepresents a hydrogen atom, a Calkyl group, or the like; B represents a Caryl group, or a 5- to 10-membered heterocyclic group; and n represents an integer of 0 or 1], a salt of the tetrahydroquinoline compound, or a solvate of the tetrahydroquinoline compound or the salt.

The present invention relates to provision of a novel compound that has an activity of promoting insulin secretion from pancreatic &#x3b2; cells and thus is useful as a prophylaxis and/or therapeutic agent for diseases caused by hyperglycemia such as diabetes mellitus, and the compound represented by the following formula (1): 

Condensed pyridine or condensed pyrimidine derivative, and medicinal agent comprising same

Disclosed is a compound which has both an angiotensin-II receptor antagonistic activity and a PPAR&#x3b3; activation activity and is useful as a prophylactic and/or therapeutic agent for hypertension, heart diseases, angina pectoris, cerebrovascular disorders, cerebral circulatory disorders, ischemic peripheral circulatory disorders, renal diseases, arteriosclerosis, inflammatory diseases, type-2 diabetes, diabetic complications, insulin resistance syndrome, syndrome X, metabolic syndrome and hyperinsulinemia. [In the formula, A represents a 5- to 10-membered heteroaryl group; Rand Rindependently represent a Calkyl group; and each of Rto Ris absent or represents H, a halogen atom, OH, NO, a halo-Calkyl group, a (substituted) Calkoxy group, a (substituted) Ccycloalkyloxy group, or a 5- to 10-membered heteroaryl group.]

Compound having 3-heteroarylpyrimidin-4-(3H)-one structure and pharmaceutical preparation containing same

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Higashimurayama, Japan

Gen Watanabe