Hamamatsu-photonics K.k.

Gen Takebe

Mitsuo Hiramatsu

Tokio Takagi

Yoichi Kawada

Kazuue Fujita

Tatsuo Dougakiuchi

Naota Akikusa

Tomonori Kawakami

Kouichiro Akiyama

A microparticle dispersion liquid manufacturing apparatusincludes a controller, a light source, an irradiation optical system, and a container. A solid objectis contained in and a solventis injected into an interior of the containerto enable attainment of a state where the solid objectis in contact with the solvent. The light sourcerepeatedly outputs pulsed light. By repeatedly irradiating the solventwith the pulsed light from the light source, expansion and contraction of the solventis made to occur repeatedly at the irradiated portion, thereby generating a pressure wave in the solvent, and the pressure wave is made to act on the solid objectto finely pulverize the solid objectand thereby manufacture a microparticle dispersion liquid in which microparticles are dispersed in the solvent. A microparticle dispersion liquid manufacturing method and manufacturing apparatus are thereby realized by which both suppression of impurity formation and an increase in efficiency of microparticle formation can be achieved readily.

Fine-particle dispersion liquid manufacturing method and fine-particle dispersion liquid manufacturing apparatus

The drug evaluation device obtains, by an attenuated reflection method using a terahertz wave, an evaluation absorption spectrum for a frequency with respect to a liquid to be evaluated. When crystalline particles are suspended in a liquid, an absorption peak having a peak area corresponding to the amount of suspension appears in its absorption spectrum. Therefore, whether or not and by what ratio crystalline particles are suspended in the liquid can be determined according to whether or not the absorption peak exists and the peak area. When amorphous particles are suspended in the liquid, the baseline of its absorption spectrum lowers according to the ratio of amorphous particles suspended in the liquid. Therefore, whether or not and by what ratio amorphous particles are suspended in the liquid can be determined according to the lowering amount of the baseline.

Drug evaluation method and drug evaluation device

A method and an apparatus enabling manufacture of a microparticle dispersion liquid at high efficiency in a short time while suppressing drug degradation, etc., are provided. In a dissolving step, a poorly soluble drug and a dispersion stabilizer are dissolved in a volatile organic solvent in a container. In a fixing step following the dissolving step, the organic solvent, contained in a solution, is eliminated by evaporation, a pellet-form residueis obtained by the organic solvent elimination, and the residueis fixed on an inner wall of the container. In a water injecting step following the fixing step, wateris injected into an interior of the container. In an irradiating step following the water injecting step, laser light, emitted from a laser light source, is irradiated on the residuefixed on the inner wall of the container, and the residueis thereby pulverized and made into microparticles and a microparticle dispersion liquid, constituted of the microparticles being dispersed in the water, is manufactured. The microparticles contain the poorly soluble drug and the dispersion stabilizer.

Microparticles, microparticle dispersion and method and apparatus for producing the same

In a dissolving step, a poorly soluble drug and a dispersion stabilizer are dissolved in a volatile organic solvent. In a fixing step, the organic solvent, contained in a solution obtained in the dissolving step, is removed by evaporation, pellet-form residuesare obtained by the organic solvent removal, and the residuesare fixed on respective bottom surfaces of a plurality of locations of a container. In a water injecting step, wateris injected into each of a plurality of recessesof the container. In an irradiating step, laser light L, emitted from a light irradiating unit, is irradiated simultaneously or successively on the residuesfixed on the respective bottom surfaces of the recessesof the container, and the residuesare thereby pulverized and made into microparticles and a microparticle dispersion liquid, constituted of the microparticles being dispersed in the water, is manufactured.

Growing community of inventors

Hamamatsu, Japan

Gen Takebe