The Penn State Research Foundation

Wayne State University

Gen Sheng Wu

Wafik S El-Deiry

Joshua E Allen

Richard Donovan Jones

Wei-Zen Wei

Marie P Piechocki

Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.

Small molecule trail gene induction by normal and tumor cells as an anticancer therapy

Small molecule TRAIL gene induction by normal and tumor cells as an anticancer therapy

The invention provides therapeutics and methods to induce a mammalian host, including a human, to produce antibodies, which agonize death receptors and cause the apoptotic death of target cells within the host's body. The therapeutics are vaccine compositions, including genetic vaccines encoding death receptor antigens of the tumor necrosis factor receptor family. Also provided are means and methods for overcoming host immunological tolerance to death receptors. The vaccines are useful against cancer cells and other death receptor bearing target cells within the host, and can be used in both therapeutic and prophylactic settings. The vaccines are also useful for diagnostic testing of the immunocompetence of a host.

Vaccine targeting cellular death receptor DR5

Growing community of inventors

Troy, MI, United States of America

Gen Sheng Wu