Amino Up Chemical Co., Ltd.

Usaien Pharmaceutical Co., Ltd.

Nagasaki University

Usien Pharmaceutical Co., Ltd.

Amino Up Co., Ltd.

Gen-ichiro Nonaka

Hajime Fujii

Takashi Nakagawa

Buxiang Sun

Lan Yuan

Young-Joon Surh

Takashi Tanaka

Hiroshi Nishioka

Isao Kohno

The present invention relates to a composition containing as its main component proanthocyanidin oligomer to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight, which is obtained by heating plant materials containing proanthocyanidin polymer or extract thereof with a substance having a phloroglucinol ring structure or resorcinol ring structure in an acidic aqueous solution, production method thereof, and uses of the composition in health products and pharmaceutical products. According to the invention, proanthocyanidin oligomer having physiological activity, to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight to such a level that the oligomer can be absorbed into living body, which has been conventionally difficult to obtain at high yield from plant raw materials, can be produced efficiently and easily.

Method of producing proanthocyanidin oligomer

Provided are: method of producing a sulfur-containing proanthocyanidin oligomer by reducing the molecular weight of proanthocyanidin in plants so that they can be readily absorbed through the intestine of an organism; and a health food composition and a pharmaceutical composition which contain the resultant sulfur-containing proanthocyanidin oligomer as an active ingredient and which are useful for treating and preventing various lifestyle-related diseases and brain diseases caused by generation of active oxygen species as well as for preventing aging.

Sulfur-containing proanthocyanidin oligomer composition and production method thereof

Sulfur-containing proanthocyanidin oligomer compositon and process for producing the same

Growing community of inventors

Saga, Japan

Gen-ichiro Nonaka