University College Dublin

Gemma Cannon

Gil Lee

Mark Platt

Peng Li

There is provided a method of aggregating a plurality of beads in a magnetic bead aggregation assay for subsequent analysis comprising: &#x2014;providing magnetic beads comprising a capture probe for binding with said target analyte; &#x2014;reacting the magnetic beads with the sample including a target analyte in a reaction chamber aggregating the magnetic beads in the presence of a magnetic field with the target analyte to allow formation of magnetic bead aggregates having physical properties detectable to enable characterization of the aggregates on an aggregate by aggregate basis using a detector to measure the physical properties of the aggregates. Further provided are a method and system for detecting analytes in a sample by characterizing the magnetic bead aggregates on an aggregate by aggregate basis by measuring physical properties of the aggregates.

Magnetic bead aggregation assay system

A flow enhanced method and system for flow non-linear magnetophoresis (F-NLM) is described. By tuning an external field frequency and the flow rate the migration velocities of different bead types may be caused to differ by several orders of magnitude over an extended range of frequencies to allow for separation of particles. Use of such efficiency in separation in bio-separation and similar assays is described.

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Dublin, Ireland

Gemma Cannon