Sintef Tto as

Spermvital as

Other

Sinvent as

Algipharma as

Tine Sa

Geir Klinkenberg

Trond Erling Ellingsen

Lars Kilaas

Arne Dessen

Sergey Zotchev

Rolf Myrvold

Elisabeth Kommisrud

Havard Sletta

Kjell Domaas Josefsen

Hanne Jørgensen

Per Bruheim

Kristin Fløgstad Degnes

Heidi Johnsen

Håvard Sletta

Espen Fjærvik

Eugenia Mariana Sandru

Espen Fjaervik

Anna Nordborg

Edvar Onsøyen

Peer Ola Hofmo

Sigrid Hakvag

Helge Holo

David William Thomas

Katja Etel Hill

Anne Hege Alm-Kristiansen

Wilhelm Robert Glomm

Kristin Flogstad Degnes

Hanne Jorgensen

Kristin FLØGSTAD Degnes

Sigrid HAKVÅG

Anne TØNDERVIK

Jorun ØYaas

The present invention relates to a kit suitable for preparing a sustained release composition, in particular for preparing a sustained release composition comprising spermatozoa embedded within an alginate matrix.

Functionalized kit for preparing hydrogels

The invention provides a new compound, a method to produce it and use of it as an antimicrobial agent, as well as pharmaceutical compositions comprising it. It is also disclosed use of actinomycetes bacteria to produce the compound (Formula III). 

Antimicrobial compound

A nucleic acid molecule comprises a nucleotide sequence: as shown in SEQ ID No. 1, which is the complement of SEQ ID No. 1, which is degenerate with SEQ ID No. 1, or which has at least 85% sequence identity with SEQ ID No. 1, or which is a part of such a sequence. The nucleic acid molecule encodes or is a complementary to a nucleic acid molecule encoding one or more polypeptides, or comprises or is complementary to a nucleic acid molecule comprising one or more genetic elements, having functional activity in the synthesis of a polyketide-based or macrolactam molecule. The nucleic acid molecule may be used to prepare a modified BE-14106 biosynthetic gene cluster for the preparation of a modified BE-14106 molecule.

NRPS-PKS gene cluster and its manipulation and utility

The present invention relates to an improved method for preparing hydrogels, such as alginate hydrogels. The hydrogels of the present invention is in particular useful for immobilization and preservation of biological material, such as cellular material, e.g. spermatozoa.

Methods for the preparation of hydrogels

Methods for the preparation of hydrogels using lipase enzymes

The present invention provides a nucleic acid molecule comprising: (a) a nucleotide sequence as shown in SEQ ID No. 1; or (b) a nucleotide sequence which is the complement of SEQ ID No. 1; or (c) a nucleotide sequence which is degenerate with SEQ ID No. 1; or (d) a nucleotide sequence having at least 85% sequence identity (preferably at least 87%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% sequence identity) with SEQ ID No. 1; or (e) a part of any one of (a) to (d), wherein said nucleic acid molecule encodes or is a complementary to a nucleic acid molecule encoding one or more polypeptides, or comprises or is complementary to a nucleic acid molecule comprising one or more genetic elements, having functional activity in the synthesis of a polyketide-based or macrolactam molecule. Particularly the invention contemplates the modification of the nucleic acid of the invention, encoding the biosynthetic machinery for the synthesis of the polyketide macrolactam BE-14106, including expressing in a microorganism the modified nucleic acid molecule. In certain aspects the modification includes introducing, mutating, deleting, replacing or inactivating a sequence encoding one or more activities or proteins encoded by said nucleic acid molecule. Other aspects of the invention include a microorganism containing the modified and unmodified nucleic acid and recovering the polyketide-based or macrolactam molecule from said microorganism.

The present invention relates to biopolymer particles for preservation of spermatozoa, wherein the spermatozoa are embedded within the biopolymer particle. The present invention also regards a method for preservation, storage and controlled delivery/release of spermatozoa, and the use of the biopolymer particles according to the present invention in breeding.

Preservation and controlled delivery / release of spermatozoa

Growing community of inventors

Heimdal, Norway

Geir Klinkenberg