Devgen Nv

Geert Karel Maria Plaetinck

Romaan Raemaekers

Thierry Andre Olivier Eddy Bogaert

Laurent Kubler

Richard Zwaal

Titus Jan Kaletta

Thierry Andre Oliver Eddy Bogaert

Els Vanbleu

Jean-Pierre Renard

Jan Octaaf De Kerpel

Thierry AndréOlivier Eddy Bogaert

The present invention concerns methods for controlling insect infestation via RNAi-mediated gene silencing, whereby the intact insect cell(s) are contacted with a double-stranded RNA from outside the insect cell(s) and whereby the double-stranded RNA is taken up by the intact insect cell(s). In one particular embodiment, the methods of the invention are used to alleviate plants from insect pests. Alternatively, the methods are used for treating and/or preventing insect infestation on a substrate or a subject in need of such treatment and/or prevention. Suitable insect target genes and fragments thereof, dsRNA constructs, recombinant constructs and compositions are disclosed.

Methods for controlling pests using RNAi

The present invention relates in generally to RNAi and its use in gene silencing. In particular, the present invention relates to methods and constructs for delivering double stranded RNA (dsRNA) to pest organisms.

Method and constructs for delivering double stranded RNA to pest organisms

Improved vector constructs useful in the expression of double-stranded RNA are provided. The constructs are particularly useful for expression of double-stranded RNA in vitro and in vivo.

Vector constructs

Growing community of inventors

Bottelare, Belgium

Geert Karel Maria Plaetinck