Umc Utrecht Holding B.v.

Tiga Tx, Inc.

Geert Jan Van Tetering

Jeanette Henrica Wilhelmina Leusen

Johannes Gerardus Maria Evers

Provided herein are engineered antibodies that comprise a modified IgA2 heavy chain constant region, pharmaceutical compositions, and methods of use. The engineered antibodies described herein comprise one or more amino acid substitutions or deletions in a constant region of an IgA2 domain that modify naturally occurring glycosylation site(s). Further provided herein are methods of treating disorders, including cancer, by administering an engineered IgA antibody described herein.

Engineered IGA antibodies and methods of use

Provided herein are engineered antibodies that comprise a modified IgA heavy chain constant region, pharmaceutical compositions, and methods of use. The engineered antibodies described herein comprise one or more amino acid substitution or deletion in a constant region of an IgA domain. Further provided herein are methods of treating disorders, including cancer, by administering an engineered IgA antibody described herein.

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Utrecht, Netherlands

Geert Jan Van Tetering