University of Georgia Research Foundation, Inc.

National Institutes of Health, a Component of the US Dept. of Health & Human Services

Medimmune Limited

Geert-Jan Boons

Margaretha Wolfert

Jun Guo

Xinghai Ning

Therese Buskas

Vladimir V Popik

Andrei A Poloukhtine

Sampat Ingale

Conrad Padraig Quinn

Russell W Carlson

Patricia P Wilkins

Elmar Kannenberg

Alok Mehta

Elke Saile

Mahalakshmi Vasan

Margreet A Wolfert

Anthony Robert Prudden

Lin Liu

Charles K Stover

Jason John Locklin

Antonio Digiandomenico

Qun Wang

Ngalle Eric Mbua

Kanar al-Mafraji

Huiqing Li

Zhen Wang

Sara V Orski

Andre Venot

Biswa Choudhury

Christine Leoff

Frederic Friscourt

Jana Rauvolfova

Kai-For Mo

Sailaja Arungundram

Petr A Ledin

Disclosed herein are oligosaccharides and intermediates useful for the production thereof. The compounds are useful as analytical standards and as intermediates for the preparation of more complex oligosaccharide and N-glycan products. The compounds may be prepared in high purity using the selective stop/go synthetic methods disclosed herein.

Oligosaccharide analytical standards

Compounds, compositions, and methods are provided for covalently linking an antibody or an antibody fragment to a cargo molecule, such as a therapeutic or a diagnostic agent, using a combination of enzymatic glycan remodeling and click chemistry. The method allows a cargo molecule to be selectively and efficiently attached post-translationally to an antibody or an antibody fragment. Also provided are antibody drug conjugates, methods of making, and uses thereof.

Site-specific antibody-drug glyconjugates and methods

Site-specific antibody-drug glycoconjugates and methods

This disclosure relates to synthetic oligosaccharide subunits of theexosaccharide Psi and uses thereof, e.g., for epitope mapping of anti-Psl antibodies, for identification of anti-Psl antibodies, and for use as vaccines. In one aspect a synthetic oligosaccharide subunit of aPsl oligosaccharide is provided, comprising the trisaccharide of formula I.

Synthetic oligosaccharide subunits of the Psl exopolysaccharide of pseudomonas aeruginosa and uses thereof

The invention provides an efficient modular chemical synthesis for heparan sulfate oligosaccharides based on orthogonal protection strategies. Modular disaccharide building blocks, themselves the product of a novel combinatorial synthesis, are combined in numerous ways to produce a range of oligosaccharides.

Heparan sulfate synthesis

The present invention provides chemical and chemo-enzymatic methods for the synthesis of a wide array of complex asymmetric multi-antennary glycans.

Compounds and methods for chemical and chemo-enzymatic synthesis of complex glycans

1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a substrate.

Alkynes and methods of reacting alkynes with 1,3-dipole-functional compounds

A glycolipopeptide comprising a carbohydrate component, a peptide component and a lipid component, for use as a therapeutic or prophylactic vaccine. Also provided are monoclonal and polyclonal antibodies that recognize the glycolipopeptide of the invention, as well as uses thereof.

Glycopeptide and uses thereof

Methods that include latent 1,3-dipole-functional compounds are disclosed herein. The latent 1,3-dipole-functional compound (e.g., an oxime) can be used to form an active 1,3-dipole-functional compound (e.g., a nitrile oxide) that can be used to react with a cyclic alkyne in a dipolar cycloaddition reaction.

Methods including latent 1,3-dipole-functional compounds and materials prepared thereby

The present invention presents the isolation, characterization and synthesis of oligosaccharides of. Also presented are antibodies that bind to such saccharide moieties and various methods of use for such saccharide moieties and antibodies.

Anthrax carbohydrates, synthesis and uses thereof

The invention provides functionalized monosaccharides and disaccharides suitable for use in synthesizing a lipid A derivative, as well as methods for synthesizing and using a synthetic lipid A derivative.

Synthetic lipid A derivative

Growing community of inventors

Athens, GA, United States of America

Geert-Jan Boons