Merck Sharp + Dohme Corp.

Gayle Scott

Leslie Joseph Street

William Robert Carling

Kevin William Moore

Michael Geoffrey Russell

Timothy Harrison

Jose Luis Castro Pineiro

Andrew Madin

Ian James Collins

Alexander Richard Guiblin

Andrew Mitchinson

A class of substituted 1,2,4-triazolo&lsqb;4,3-b&rsqb;pyridazine derivatives, possessing a fluoro-substituted phenyl ring at the 3-position and a heteroaryl-methoxy moiety at the 6-position, are selective ligands for GABA receptors, in particular having high affinity for the &agr;2 and/or &agr;3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.

Triazolo-pyridazine derivatives as ligands for GABA receptors

1,2,4-triazolo&lsqb;4,3-b&rsqb;pyridazine derivatives, possessing a fluoro-substituted phenyl ring at the 3-position and a heteroaryl-alkoxy moiety at the 6-position, are selective ligands for GABA receptors, in particular having high affinity for the &agr;2 and/or &agr;3 subunit thereof, are useful in the treatment of anxiety and convulsions.

Pyrazolo-triazine derivatives as ligands for GABA receptors

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Lanark, United Kingdom

Gayle Scott