North Carolina State University

Gavin Williams

Christian Kasey

Yiwei Li

Yasamin Moazami

Joshua G Pierce

David C Muddiman

Philip L Loziuk

The present disclosure relates to high-throughput detection of polyketides using genetically encoded biosensors.

Genetically encoded biosensors for detection of polyketides

Provided herein are isotopically labeled reagents, including isotopically labeled small molecules and peptides, that can be used to detect and/or quantify &#x3b2;-N-methylamino-L-alanine (BMAA) in a sample. The reagents can be used as stable isotope labeled standards in analytical methods, including in conjunction with mass spectrometry, to detect and/or quantify BMAA in a sample, such as a protein sample from a subject.

Materials and methods for detection and quantification of &#x3b2;-N-methylamino-L-alanine

Growing community of inventors

Raleigh, NC, United States of America

Gavin Williams