Merck Sharp + Dohme Corp.

Merck + Co., Inc.

Gavin William Stewart

Stephen Philip Keen

Carl A Baxter

Shane W Krska

Peter Emmanuel Maligres

Lushi Tan

Edward Cleator

Jeremy Peter Scott

Ian Frank Cottrell

Faye Sheen

David R Lieberman

Qinghao Chen

Brian Christopher Bishop

Antony John Davies

Cameron Cowden

Neil A Strotman

Karel Marie Joseph Brands

Timothy James Wright

Debra J Wallace

Andrew Gibb

Steven Fraser Oliver

Edward Cleartor

Timothy Wright

This invention provides novel processes for the preparation of compounds such as 3-[(1S,2S)-2-hydroxycyclohexyl]-6-[(6-methylpyridin-3-yl)methyl]benzo[h]-quinazolin-4(3H)-one, salts and derivatives thereof. The compounds synthesized by the processes of the invention are useful for treating Alzheimer's disease and other diseases (e.g., cognitive impairment, schizophrenia, pain disorders, and sleep disorders) mediated by the muscarinic M1 receptor.

Process for making M1 receptor positive allosteric modulators

The present invention is directed to processes for preparing a diazepane compound which is an antagonist of orexin receptors, and which is useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is further directed to crystalline forms of this diazepane compound and pharmaceutical compositions thereof.

Process for the preparation of an orexin receptor antagonist

An enantioselective route to compounds of formula I is disclosed:  The compounds of formula I are key intermediates in the synthesis of compounds useful in treatment of Alzheimer's disease.

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The present invention relates to the synthesis of intermediates for the preparation of compounds of formula (A): wherein n is 2 or 3 and various salt forms of these compounds. The compounds of formula (A) are useful as &#x3b1;&#x3bd;&#x3b2;3 receptor antagonists 

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Hertfordshire, United Kingdom

Gavin William Stewart