Astrazeneca Ab

Gavin O'Mahony

Karl Henrik Edman

Andrew Turner

Michael Kossenjans

Philip Cornwall

Johan Kajanus

Carl Anders Hogner

Karl Anders Hogner

Karl Edman

Disclosed are certain derivatives of benzoxazinone amides of formula (I), or pharmaceutically acceptable salts thereof, (Formula (I)) that act as mineralocorticoid (MR) receptor modulators that may reduce oxidative stress in endothelium and hence improve vascular function, to methods for their potential therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds. 

Benzoxazinone amides as mineralocorticoid receptor modulators

Disclosed are certain derivatives of benzoxazinone amides of formula (I), or pharmaceutically acceptable salts thereof, that act as mineralocorticoid (MR) receptor modulators that may reduce oxidative stress in endothelium and hence improve vascular function, to methods for their potential therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.

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Molndal, Sweden

Gavin O'Mahony