The General Hospital Corporation

Zimmer Gmbh

Cambridge Polymer Group, Inc.

Gavin Braithwaite

Orhun K Muratoglu

Steven Charlebois

Stephen H Spiegelberg

Gareth H McKinley

Brian H Thomas

Harry E Rubash

Donald L Yakimicki

Henrik Malchau

James Mason

Yuri Svirkin

Bayen Lee Miller

A method of forming thiolated poly(vinyl alcohol) hydrogels including reacting, in the presence of an acid, compounds containing a thiol functional group and a hydroxyl reactive group with one or more hydroxyl groups of poly(vinyl alcohol) via said hydroxyl reactive group, thereby forming thiolated poly(vinyl alcohol). The method further including reacting the thiol functional group of said compounds with a thiol reactive group of a crosslinker, thereby forming a hydrogel.

Thiolated PEG-PVA hydrogels

Systems and methods provide patient position information to a user. A patient positioning device is placed on a patient in a predefined location. The patient positioning device determines a relative patient position with respect to at least one known reference axis. The patient positioning device communicates patient position information including or with reference to the at least one known reference axis. The communicated patient position information allows the user to position the patient and/or a surgical tool using the communicated patient position information.

Patient positioning systems and methods

Various embodiments of mosaicplasty constructs and methods for implanting the constructs into anatomical structures. The mosaicplasty constructs may be formed from artificial materials and may include a hard articulating portion and a relatively softer elastic, support portion. The mosaicplasty constructs may include bone ingrowth materials to facilitate ingrowth of bone and other tissues into the construct. The mosaicplasty constructs may also be at least partially formed of hydrogel materials.

Mosaicplasty constructs

Growing community of inventors

Cambridge, MA, United States of America

Gavin Braithwaite