University Of Zürich

Gautham Varadamsetty

Andreas Plückthun

Michael Tobias Stumpp

Fabio Parmeggiani

Anders Peter Larsen

Riccardo Pellarin

Andreas PLÜCKTHUN

The invention relates to collections of target-specific designed binding proteins based on armadillo repeat proteins, and to a method of generating them. Designed armadillo repeat proteins are based on consensus sequences of single armadillo repeat units. These repeat proteins can be used as scaffolds for peptide recognition. Such a scaffold provides a binding mode that is in principle the same for every small recognizable unit, e.g. an amino acid or dipeptide, allowing a precise and modular recognition of a peptide in extended conformation. The method allows to generate a series of modules recognizing these simple units, and to combine such building blocks to create a binding site for any desired peptide target without performing additional selections.

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Zurich, Switzerland

Gautham Varadamsetty