Battelle Memorial Institute

Gaurav Sharma

Chad Edward Bouton

Nicholas Annetta

Patrick Ganzer

David A Friedenberg

Samuel Colachis

Amy M Heintz

Steven Risser

Thomas D Haubert

George Brand

Andrew Sweeney

Stephanie Kute

Matthew Edward Mowrer

Raymond Richard Zaborski

Ramanathan S Lalgudi

Alexander Morrow

Jeffrey A Friend

Bradley Charles Glenn

Jeffrey L Ellis

John Bartholomew

Collin F Dunlap

Rachel Thurston

Michael A Schwemmer

Douglas E Boyd

C Alexander Morrow

Joshua R Branch

Amanda Noonan

Jeffrey Friend

Steven M Risser

Michael Schwemmer

A tremor suppression device includes a garment wearable on an anatomical region and including electrodes contacting the anatomical region when the garment is worn on the anatomical region, and an electronic controller configured to: detect electromyography (EMG) signals as a function of anatomical location and time using the electrodes; identify tremors as a function of anatomical location and time based on the EMG signals; and apply neuromuscular electrical stimulation (NMES) at one or more anatomical locations as a function of time using the electrodes to suppress the identified tremors.

Neurosleeve for closed loop EMG-FES based control of pathological tremors

The present disclosure relates to neuromuscular stimulation and sensing cuffs. The neuromuscular stimulation cuff has at least two fingers and a plurality of electrodes disposed on each finger. More generally, the neuromuscular stimulation cuff includes an outer, reusable component and an inner, disposable component. One or more electrodes are housed within the reusable component. The neuromuscular stimulation cuff may be produced by providing an insulating substrate layer, forming a conductive circuit on the substrate layer to form a conductive circuit layer, adhering a cover layer onto the conductive circuit layer to form a flexible circuit, and cutting at least one flexible finger from the flexible circuit. The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement.

Neural sleeve for neuromuscular stimulation, sensing and recording

The present disclosure relates generally to systems, methods, and devices for interpreting neural signals to determine a desired movement of a target, transmitting electrical signals to the target, and dynamically monitoring subsequent neural signals or movement of the target to change the signal being delivered if necessary, so that the desired movement is achieved. In particular, the neural signals are decoded using a feature extractor, decoder(s) and a body state observer to determine the electrical signals that should be sent.

Systems for neural bridging of the nervous system

At least one electrical brain signal is received from a patient and is demultiplexed into an efferent motor intention signal and at least one afferent sensory signal (such as an afferent touch sense signal and/or an afferent proprioception signal). A functional electrical stimulation (FES) device is controlled to apply FES to control a paralyzed portion of the patient that is paralyzed due to a spinal cord injury of the patient. The controlling of the FES device is based on at least the efferent motor intention signal. A demultiplexed afferent touch sense signal may be used to control a haptic device. The afferent sensory signal(s) may be used to adjust the FES control.

Motor function neural control interface for spinal cord injury patients

A garment is wearable on an anatomical region and includes electrodes contacting the anatomical region when the garment is worn on the anatomical region. An electronic controller is configured to detect electromyography (EMG) signals as a function of anatomical location and time using the electrodes, and identify tremors as a function of anatomical location and time based on the EMG signals.

Neurosleeve for assessment of pathological tremors

An activity assistance system includes a video camera arranged to acquire video of a person performing an activity, an output device configured to output human-perceptible prompts, and an electronic processor programmed to execute an activity script. The script comprises a sequence of steps choreographing the activity. The execution of each step includes presenting a prompt via the output device and detecting an event or sequence of events subsequent to the presenting of the prompt. Each event is detected by performing object detection on the video to detect one or more objects depicted in the video and applying one or more object-oriented image analysis functions to detect a spatial or temporal arrangement of one or more of the detected objects. Each event detection triggers an action comprising at least one of presenting a prompt via the output device and and/or going to another step of the activity script.

Activity assistance system

A portable and wearable hand-grasp neuro-orthosis is configured for use in a home environment to restore volitionally controlled grasp functions for a subject with a cervical spinal cord injury (SCI). The neuro-orthosis may include: a wearable sleeve with electrodes; electronics for operating the wearable sleeve to perform functional electrical stimulation (FES) and electromyography (EMG), the electronics configured for mounting on a wheelchair; and a controller configured for mounting on a wheelchair. The controller controls the electronics to read EMG via the sleeve, decode the read EMG to determine an intent of the user, and operate the electronics to apply FES via the sleeve to implement the intent of the user. The neuro-orthosis may restore hand function. The controller may include a display arranged to be viewed by the subject, for example mounted on an articulated arm attached to the wheelchair.

Portable and wearable hand-grasp neuro-orthosis

Systems and methods for neural bridging of the nervous system

A therapeutic or diagnostic device comprises a wearable electrodes garment including electrodes disposed to contact skin when the wearable electrodes garment is worn, and an electronic controller operatively connected with the electrodes. The electronic controller is programmed to perform a method including: receiving surface electromyography (EMG) signals via the electrodes and extracting one or more motor unit (MU) action potentials from the surface EMG signals. The method may further include identifying an intended movement based at least on features representing the one or more extracted MU action potentials and delivering functional electrical stimulation (FES) effective to implement the intended movement via the electrodes of the wearable electrodes garment. The method may further include generating a patient performance report based at least on a comparison of features representing the one or more extracted MU action potentials and features representing expected and/or baseline MU action potentials for a known intended movement.

Control of functional electrical stimulation using motor unit action potentials

A chronically implanted medical device is disclosed that has an outermost layer formed from a conjugate of a polymer with lipoic acid, the conjugate having free 1,2-dithiolane groups. It is contemplated that this layer scavenges reactive oxygen species, i.e. acts as an antioxidant, and thus reduces inflammation and other adverse effects around the implant itself.

Implant with reactive oxygen species scavenging coating

The present disclosure relates generally to systems, methods, and devices for closed loop deep brain stimulation. In particular, a neural signal is measured and provided to software. The software includes a feature generator and a brain network model that takes the neural signal and estimates other neural signals that are not directly measured, and operates as a model of the brain. The software determines a stimulation signal to be sent to stimulating electrodes. Estimated signals by the brain network model are continuously compared to actual signals from the brain. The closed loop feedback system advantageously allows for electrical stimulation levels and patterns to be continuously updated while delivered to a patient.

Closed loop deep brain stimulation systems and methods

Growing community of inventors

Lewis Center, OH, United States of America

Gaurav Sharma