Sun Pharma Advanced Research Company Limited

Gaurav Sanjivkumar Sheth

Trinadha Rao Chitturi

Jiten Ranchhodbhai Patel

Gopalkumar Chimanlal Patel

Rajamannar Thennati

Sanjay Nandlal Mandhane

Prabal Sengupta

Sabbirhusen Yusufbhai Chimanwala

Chitturi Trinadha Rao

Samir Rameshchandra Shah

Saikat Maity

Sairam V V M Kalapatapu

Tushar Mukund Jarag

Gulamnizami Abdulsattar Qureshi

Vaibhav Jain

V S N Murty Kadiyala

Umesh Vishnu Chaudhari

Aishwarya Hampiholi

Raj Gopal Venkat

The present invention relates to novel compounds useful as malic enzyme (ME) inhibitors, processes for their preparation and use of these compounds for the therapeutic treatment of disorders mediated by ME such as cancers (e.g. pancreatic ductal adenocarcinoma (PDAC)) in humans. The novel compounds have a structure according to Formula I or a pharmaceutically acceptable salt, stereoisomer or deuterated analog thereof, wherein X, R, Rand Y are as described herein.

Malic enzyme inhibitors

The present invention relates to crystalline forms of S-[4-(3-fluoro-3-methylbutyryloxy)but-2-ynyl] 6&#x3b1;,9&#x3b1;-difluoro-17&#x3b1;-(furan-2-yl)carbonyloxy-11&#x3b2;-hydroxy-16&#x3b1;-methyl-3-oxoandrosta-1,4-diene-17&#x3b2;-carbothioate, an anti-inflammatory and anti-allergic glucocorticoid compound.

Crystalline forms of S-[4-(3-fluoro-3-methylbutyryloxy)but-2-ynyl] 6-&#x3b1;,9-&#x3b1;-difluoro-17-&#x3b1;-(furan-2-yl)carbonyloxy-11-&#x3b2;-hydroxy-16-&#x3b1;-methyl-3-oxoandrosta-1,4-diene-17-&#x3b2;-carbothioate

The present invention relates to methods of treatment of inflammatory conditions using S-[4-(3-fluoro-3-methylbutyryloxy)-but-2-ynyl]6&#x3b1;,9&#x3b1;-difluoro-17&#x3b1;-(furan-2-yl)carbonyloxy-11&#x3b2;-hydroxy-16&#x3b1;-methyl-3-oxoandrosta-1,4-diene-17&#x3b2;-carbothioate (compound of formula I), a novel anti-inflammatory compound of the androstane series and its processes of preparation. 

[object Object]

The invention provides 11&#x3b2;-hydroxyandrosta-4-ene-3-one compounds of Formula I, or physiologically acceptable salts or solvates thereof: wherein Rrepresents a moiety selected from a group consisting of (A), (B) and (C), with a proviso that when Rrepresents moiety (C), Z is S: 

11&#x3b2;-hydroxyandrosta-4-ene-3-ones

The present invention relates to compounds of formula I or salts thereof, wherein, Ris selected from the group consisting of hydrogen and R; Ris selected from the group consisting of hydrogen, acetyl and R; Ris selected from the group consisting of alkyl, &#x2014;O-alkyl, &#x2014;NH-alkyl, aryl and heterocyclyl; Rrepresents a moiety (A) wherein, X is selected from the group consisting of a single bond, alkylene, alkenylene, alkynylene, arylene or a heterocyclylene moiety; Rand Rare same or different and are independently selected from hydrogen, alkyl, aryl or heterocyclyl; or Rand Rmay form together with the nitrogen atom to which they are attached a heterocyclyl ring system. 

Hydrazide containing taxane conjugates

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Baroda, India

Gaurav Sanjivkumar Sheth