Massachusetts Institute of Technology

Gaurav Rohatgi

David L Trumper

Linda G Griffith

Collin Edington

Duncan Freake

Luis Soenksen

Brij Mohan Bhushan

Mohan Brij Bhushan

Timothy Kassis

Fluidic multiwell bioreactors are provided as a microphysiological platform for in vitro investigation of multi-organ crosstalks for an extended period of time of at least weeks and months. The disclosed platform is featured with one or more improvements over existing bioreactors, including on-board pumping for pneumatically driven fluid flow, a redesigned spillway for self-leveling from source to sink, a non-contact built-in fluid level sensing device, precise control on fluid flow profile and partitioning, and facile reconfigurations such as daisy chaining and multilayer stacking. The platform supports the culture of multiple organs in a microphysiological, interacted systems, suitable for a wide range of biomedical applications including systemic toxicity studies and physiology-based pharmacokinetic and pharmacodynamic predictions. A process to fabricate the disclosed bioreactors is also provided.

Modular organ microphysiological system with integrated pumping, leveling, and sensing

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Boston, MA, United States of America

Gaurav Rohatgi